2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Delequamine

Delequamine  (Synonyms: RS-15385-197)

目录号: HY-106874
产品使用指南

摩尔计算器

Delequamine (RS-15385-197) 是一种具有口服活性和选择性的 α2-肾上腺素受体 (α2-adrenergic receptor) 拮抗剂，对大鼠皮质中的 α2-肾上腺素受体的 pKi 为 9.5。Delequamine 对 5-HT1A 受体和 α1-肾上腺素受体的选择性超过 1000 倍。Delequamine 可用于勃起功能障碍的研究。

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Delequamine Chemical Structure

Delequamine Chemical Structure

CAS No. : 119905-05-4

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Other Forms of Delequamine:

Delequamine 相关抗体

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α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Delequamine (RS-15385-197) is an orally active and selective α2-adrenergic receptor antagonist with a pKi of 9.5 for α2-adrenoceptors in rat cortex. Delequamine shows >1000 fold selectivity against 5-HT1A receptors and α1-adrenoceptors. Delequamine can be used for the study of erectile dysfunction[1].

IC50 & Target[1]

α2-adrenergic receptor

9.5 (pKi)

α1-adrenergic receptor

5.3 (pKi)

体内研究
(In Vivo)

Delequamine (0.4-6.4 mg/kg; 口服，单剂量) 在未经过训练的雄性大鼠与经过雌激素-孕激素处理、性接受状态的雌性大鼠接触的模型中能以剂量依赖的方式增加性行为评分。并且 Delequamine (0.4 mg/kg; 口服; 单剂量) 和 8-OH-DPAT (HY-112061) ( 0.1 mg/kg; 皮下注射) 联用能增加大鼠爬跨、插入和射精的百分比，缩短了射精潜伏期并减少插入次数[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

350.48

Formula

C18H26N2O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Delequamine 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Delequamine119905-05-4RS-15385-197Adrenergic ReceptorBeta Receptorα2-adrenergic receptor antagonistorally activeerectile dysfunctionInhibitorinhibitorinhibit

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