2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. DIBA-Cy5

DIBA-Cy5 是一种 DIBA 荧光拮抗剂，由 DIBA-炔结合 Cyanine5 荧光团 (Cy5) 和聚乙二醇 (PEG) 生物分子组成。DIBA-Cy5 可以作为荧光配体，适合通过点击化学附着探针。DIBA-Cy5 对 type-2 mAChR (M2R) 具有很高的结合亲和力 ( Kd=1.80 nM)，可直接染色小鼠窦房结的 M2R 受体。

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DIBA-Cy5 Chemical Structure

DIBA-Cy5 Chemical Structure

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DIBA-Cy5 相关抗体

Top Publications Citing Use of Products

查看 mAChR 亚型特异性产品:

查看所有亚型
mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DIBA-Cy5 is a fluorescent DIBA antagonist made up be DIBA-alkyne binding Cyanine5 fluorophores (Cy5) and polyethylene glycol (PEG) biomolecules. DIBA-Cy5 can serve as a fluorescent ligand, suitable for probe attachment through click chemistry. DIBA-Cy5 exerts a high binding affinity to type-2 mAChR (M2R) with the Kd value of 1.80 nM, can directly stain M2R receptors in the sinoatrial node of a mouse heart[1].

IC50 & Target[1]

mAChR2

1.80 nM (Kd)

mAChR1

104.5 nM (Kd)

体外研究
(In Vitro)

DIBA-Cy5 (0.01 nM-1 mM; 5 h) shows selective binding property for type-2 mAChR (M2R) over M1R, with Kd of 1.08 nM and 104.5 nM, respectively[1].
DIBA-Cy5 (10 nM; 3 h) exerts the competitive binding mode with orthosteric antagonist Atropine (HY-B1205)/allosteric modulator LY2119620 (HY-15885), indicating a dualsteric binding mode of the DIBA-type antagonist to M2R[1].
DIBA-Cy5 (50 nM; 16 h) results direct staining to M2R receptors in the sinoatrial node of a mouse heart. DIBA-Cy5 can be used binding assays that screen compounds for M2R as the receptor target[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DIBA-Cy5 相关抗体:
分子量

1360.71

Formula

C69H89N11O12S3
Emission (Em)

668
Excitation (Ex)

647
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DIBA-Cy5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DIBA-Cy5mAChRMuscarinic acetylcholine receptorclick chemistryprobeCyanine5Cy5PEGpolyethylene glycolfluorescent ligandInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-151801
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