2. Cell Cycle/DNA Damage Antibody-drug Conjugate/ADC Related
  3. DNA/RNA Synthesis ADC Cytotoxin
  4. Dideoxy-amanitin

Dideoxy-amanitin (compound 2) 是一种 α-Amanitin (HY-19610) 衍生物，是一种强效和选择性的 RNA 聚合酶 II 变结构抑制剂，其 IC50 值为 74.2 nM。

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Dideoxy-amanitin Chemical Structure

Dideoxy-amanitin Chemical Structure

CAS No. : 58255-46-2

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Dideoxy-amanitin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dideoxy-amanitin (compound 2), an α-Amanitin (HY-19610) derivative, is a potent and selective RNA polymerase II allosteric inhibitor with an IC50 value of 74.2 nM[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO IC50
1.3 μM
Compound: Dideoxy amanitin
Cytotoxicity against chinese hamster CHO cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against chinese hamster CHO cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 35696491]
体外研究
(In Vitro)

Dideoxy-amanitin (compound 2; 0.078-20 μM; 24 h) has cell cytotoxicity in CHO (Chinese hamster ovary) cells with an IC50 value of 0.3 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Dideoxy-amanitin 相关抗体:

Cell Viability Assay[1]

Cell Line: CHO (Chinese hamster ovary) cells
Concentration: 0.078-20 μM
Incubation Time: 24 hours
Result: Decreased cell proliferation in a dose-depengdent manner.
分子量

886.97

Formula

C39H54N10O12S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Dideoxy-amanitin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dideoxy-amanitin58255-46-2DNA/RNA SynthesisADC CytotoxinADC Payloadα-Amanitinantibody-drug conjugateshydroxyprolineInhibitorinhibitorinhibit

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产品名称：
Dideoxy-amanitin
目录号：
HY-148231
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