2. Cell Cycle/DNA Damage Antibody-drug Conjugate/ADC Related
  3. DNA/RNA Synthesis ADC Cytotoxin
  4. Dideoxy-amanitin

Dideoxy-amanitin (compound 2) 是一种 α-Amanitin (HY-19610) 衍生物，是一种强效和选择性的 RNA 聚合酶 II 变结构抑制剂，其 IC50 值为 74.2 nM。

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Dideoxy-amanitin Chemical Structure

Dideoxy-amanitin Chemical Structure

CAS No. : 58255-46-2

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Dideoxy-amanitin 相关抗体

Top Publications Citing Use of Products

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Auristatin Calicheamicins Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dideoxy-amanitin (compound 2), an α-Amanitin (HY-19610) derivative, is a potent and selective RNA polymerase II allosteric inhibitor with an IC50 value of 74.2 nM[1].

体外研究
(In Vitro)

Dideoxy-amanitin (compound 2; 0.078-20 μM; 24 h) has cell cytotoxicity in CHO (Chinese hamster ovary) cells with an IC50 value of 0.3 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Dideoxy-amanitin 相关抗体:

Cell Viability Assay[1]

Cell Line: CHO (Chinese hamster ovary) cells
Concentration: 0.078-20 μM
Incubation Time: 24 hours
Result: Decreased cell proliferation in a dose-depengdent manner.
分子量

886.97

Formula

C39H54N10O12S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Dideoxy-amanitin 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dideoxy-amanitin58255-46-2DNA/RNA SynthesisADC CytotoxinADC Payloadα-Amanitinantibody-drug conjugateshydroxyprolineInhibitorinhibitorinhibit

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产品名称：
Dideoxy-amanitin
目录号：
HY-148231
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