2. Anti-infection
  3. Parasite
  4. Dieugenol

Dieugenol  (Synonyms: Bis-eugenol; Dehydrodieugenol)

目录号: HY-130743
产品使用指南

摩尔计算器

Dieugenol 是一种新木脂素，存在于 N. leucantha 中，具有抗氧化和抗原虫活性。在无细胞测定中，它抑制硫代巴比妥酸反应物质 (TBARS) 的形成并清除超氧化物阴离子，但不清除羟基自由基。它对克氏锥虫无鞭毛体和锥鞭毛体具有抗锥虫活性（IC50s 分别为 15.1 和 11.5 μM），但对 NCTC L-929 成纤维细胞具有细胞毒性，50% 细胞毒性浓度 (CC50) 值为 58.2 μM。Dieugenol (15 μM) 会破坏克氏锥虫锥鞭毛体质膜的完整性，但不会在锥鞭毛体或 LPS 刺激和未刺激的分离小鼠腹膜巨噬细胞中诱导活性氧 (ROS) 的产生。

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Dieugenol Chemical Structure

Dieugenol Chemical Structure

CAS No. : 4433-08-3

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规格 价格 是否有货 数量
1 mg ￥650
1 - 2 周
5 mg ￥2400
1 - 2 周
10 mg ￥4000
1 - 2 周
25 mg 现货 1 - 2 周
50 mg   询价  
100 mg   询价  

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Dieugenol 相关抗体

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dieugenol is a neolignan that has been found in N. leucantha and has antioxidative and antiprotozoal activities. It inhibits the formation of thiobarbituric acid reactive substances (TBARS) and scavenges superoxide anions, but not hydroxyl radicals, in cell-free assays. It has anti-trypanosomal activity against T. cruzi amastigotes and trypomastigotes (IC50s=15.1 and 11.5 μM, respectively) but is cytotoxic to NCTC L-929 fibroblasts with a 50% cytotoxic concentration (CC50) value of 58.2 μM.2 Dieugenol (15 μM) disrupts the integrity of the T. cruzi trypomastigote plasma membrane but does not induce the production of reactive oxygen species (ROS) in trypomastigotes or LPS-stimulated and unstimulated isolated mouse peritoneal macrophages.

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HL-60 IC50
> 100 μM
Compound: 21
Antiproliferative activity against human HL60 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human HL60 cells after 48 hrs by sulforhodamine B assay
[PMID: 22424614]
MOLT-4 IC50
> 100 μM
Compound: 21
Antiproliferative activity against human MOLT4 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human MOLT4 cells after 48 hrs by sulforhodamine B assay
[PMID: 22424614]
PC-3 IC50
> 100 μM
Compound: 21
Antiproliferative activity against human PC3 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human PC3 cells after 48 hrs by sulforhodamine B assay
[PMID: 22424614]
分子量

326.39

Formula

C20H22O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Dieugenol 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dieugenol4433-08-3Bis-eugenol DehydrodieugenolParasiteInhibitorinhibitorinhibit

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