2. Immunology/Inflammation GPCR/G Protein Neuronal Signaling Membrane Transporter/Ion Channel Metabolic Enzyme/Protease
  3. Histamine Receptor Potassium Channel Endogenous Metabolite
  4. Dimethindene

Dimethindene 是一种有效的选择性组胺H1 (histamine H1) 拮抗剂。Dimethindene 损害皮肤伤口愈合。Dimethindene 可阻断 K+ 电流。

该游离形式化合物不稳定，推荐具有相同生物学活性的稳定盐形式 Dimethindene maleate。

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Dimethindene Chemical Structure

Dimethindene Chemical Structure

CAS No. : 5636-83-9

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Dimethindene 的其他形式现货产品:

Customer Review

Other Forms of Dimethindene:

Dimethindene 相关抗体

Top Publications Citing Use of Products

查看 Histamine Receptor 亚型特异性产品:

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H1 Receptor H2 Receptor H3 Receptor H4 Receptor Histamine Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dimethindene is a potent, selective histamine H1 antagonist. Dimethindene impairs cutaneous wound healing (WH). Dimethindene can block K+ currents[1][2].

体外研究
(In Vitro)

Dimethindene (5-500 μM; follicle-enclosed Xenopus oocytes) decreases Cromakalim cromakalim-induced K+ currents with an IC50 value of 29.5 μM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Dimethindene 相关抗体:
体内研究
(In Vivo)

Dimethindene (0.25 mg; i.p.; once; C57BL/6 mice with skin WH) impaires cutaneous wound healing (WH) and delays skin wound closure[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice with skin WH[1]
Dosage: 0.25 mg
Administration: intraperitoneal injection; once
Result: Delayed skin wound closure as compared to vehicle treated mice.
分子量

292.42

Formula

C20H24N2
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Dimethindene 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Dimethindene5636-83-9Histamine ReceptorPotassium ChannelEndogenous MetaboliteKcsAcutaneous wound healingK+ currentsfollicle-enclosed Xenopus oocytesInhibitorinhibitorinhibit

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