2. Immunology/Inflammation GPCR/G Protein Neuronal Signaling Metabolic Enzyme/Protease
  3. Histamine Receptor Endogenous Metabolite
  4. Dimethindene maleate

Dimethindene maleate 

目录号: HY-13710A 纯度: 99.92%
COA 产品使用指南

摩尔计算器

Dimethindene maleate 是一种选择性的 histamine H1 拮抗剂，具有抗组胺效应。Dimethindene maleate 可用于过敏性反应的研究。

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Dimethindene maleate Chemical Structure

Dimethindene maleate Chemical Structure

CAS No. : 3614-69-5

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Free Sample (0.1 - 0.2 mg)   Apply now  
1 mg ￥380
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5 mg ￥1000
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10 mg ￥1350
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25 mg ￥2300
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50 mg ￥3900
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Customer Review

Other Forms of Dimethindene maleate:

Dimethindene maleate 相关抗体

Top Publications Citing Use of Products

查看 Histamine Receptor 亚型特异性产品:

查看所有亚型
H1 Receptor H2 Receptor H3 Receptor H4 Receptor Histamine Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dimethindene maleate is a selective histamine H1 antagonist with antihistamine effects. Dimethindene maleate can be used for the research of hypersensitivity reactions[1][2][3].

IC50 & Target

IC50: 29.5 μM (cromakalim-induced K＋ currents), 49 μM (Y-26763-induced K＋ currents)[2]
体外研究
(In Vitro)

Dimethindene maleate (1-1000 μM) suppresses the cromakalim-induced/glibenclamide-sensitive K＋ currents in a concentration-dependent and reversible manner with an IC50 value of 29.5 μM[2].
Dimethindene maleate (1-1000 μM) inhibits Y-26763-induced glibenclamide-sensitive K＋ currents with an IC50 value of 49 μM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Dimethindene maleate 相关抗体:
体内研究
(In Vivo)

Dimethindene maleate (0.25 mg; i.p. once) affects wound healing in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice with wound healing[1]
Dosage: 0.25 mg
Administration: Intraperitoneal injection; 0.25 mg once
Result: Significantly delayed skin wound and only showed wound closure impairment in the initial phase wound healing.
分子量

408.49

Formula

C24H28N2O4
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 125 mg/mL (306.01 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.4480 mL 12.2402 mL 24.4804 mL
5 mM 0.4896 mL 2.4480 mL 4.8961 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Dimethindene maleate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4480 mL 12.2402 mL 24.4804 mL 61.2010 mL
5 mM 0.4896 mL 2.4480 mL 4.8961 mL 12.2402 mL
10 mM 0.2448 mL 1.2240 mL 2.4480 mL 6.1201 mL
15 mM 0.1632 mL 0.8160 mL 1.6320 mL 4.0801 mL
20 mM 0.1224 mL 0.6120 mL 1.2240 mL 3.0601 mL
25 mM 0.0979 mL 0.4896 mL 0.9792 mL 2.4480 mL
30 mM 0.0816 mL 0.4080 mL 0.8160 mL 2.0400 mL
40 mM 0.0612 mL 0.3060 mL 0.6120 mL 1.5300 mL
50 mM 0.0490 mL 0.2448 mL 0.4896 mL 1.2240 mL
60 mM 0.0408 mL 0.2040 mL 0.4080 mL 1.0200 mL
80 mM 0.0306 mL 0.1530 mL 0.3060 mL 0.7650 mL
100 mM 0.0245 mL 0.1224 mL 0.2448 mL 0.6120 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dimethindene3614-69-5Histamine ReceptorEndogenous Metabolitexenopus oocytepromethazinewound healingglibenclamidecromakalimmiceInhibitorinhibitorinhibit

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目录号：
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