2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. DL-Acetylshikonin

DL-Acetylshikonin 是一种非选择性、可逆的 cytochrome P450 抑制剂，IC50 为 1.4-4.0 μM。DL-Acetylshikonin 具有抗癌和抗炎活性。

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DL-Acetylshikonin Chemical Structure

DL-Acetylshikonin Chemical Structure

CAS No. : 54984-93-9

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规格 是否有货
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Other Forms of DL-Acetylshikonin:

DL-Acetylshikonin 相关抗体

Top Publications Citing Use of Products

查看 Cytochrome P450 亚型特异性产品:

查看所有亚型
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DL-Acetylshikonin is a non-selective, reversible cytochrome P450 inhibitor with IC50 values of 1.4-4.0 μM. DL-Acetylshikonin has anti-cancer and anti-inflammatory activities[1].

IC50 & Target[1]

CYP2C8

1.4 μM (IC50)

CYP2B6

2.0 μM (IC50)

CYP3A

2.3 μM (IC50)

CYP2C19

2.5 μM (IC50)

CYP2D6

2.5 μM (IC50)

CYP2E1

2.7 μM (IC50)

CYP2C9

3.3 μM (IC50)

CYP2J2

3.3 μM (IC50)

CYP2A6

3.8 μM (IC50)

CYP1A2

4.0 μM (IC50)

体外研究
(In Vitro)

DL-Acetylshikonin 抑制 CYP3A 介导的睾酮 (testosterone) 和 Nifedipine (HY-B0284) 代谢，IC50 值分别为 5.2 μM 和 3.0 μM，表明其以不依赖底物的方式抑制 CYP3A 活性[1]。
DL-Acetylshikonin 不是一种时间依赖性抑制剂[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DL-Acetylshikonin 相关抗体:
分子量

330.33

Formula

C18H18O6
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DL-Acetylshikonin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DL-Acetylshikonin54984-93-9Cytochrome P450CYPsanti-canceranti-inflammatoryCYPInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-N2181A
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