2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. Dopamine D2 receptor agonist-2

Dopamine D2 receptor agonist-2 

目录号: HY-151515
产品使用指南

摩尔计算器

Dopamine D2 receptor agonist-2 (compound 36) 是一种有效的多巴胺 D2 受体 (D2 receptor) 偏激动性配体，Ki 为 11.2 nM。Dopamine D2 receptor agonist-2 可用于研究抗精神病。

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Dopamine D2 receptor agonist-2 Chemical Structure

Dopamine D2 receptor agonist-2 Chemical Structure

CAS No. : 1610591-93-9

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规格 价格 是否有货 数量
1 mg ￥631
1 - 2 周
5 mg   询价  
10 mg   询价  

* Please select Quantity before adding items.

Customer Review

Dopamine D2 receptor agonist-2 相关抗体

Top Publications Citing Use of Products

查看 Dopamine Receptor 亚型特异性产品:

查看所有亚型
Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dopamine D2 receptor agonist-2 (compound 36) is a potent dopamine D2 receptor biased agonism ligand with an Ki value of 11.2 nM. Dopamine D2 receptor agonist-2 can be used to research antipsychosis[1].

IC50 & Target

Ki: 11.2 nM (dopamine D2 receptor)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO EC50
0.3 nM
Compound: 36
Agonist activity at human D2L receptor expressed in FlpIn CHO cells assessed as inhibition of forskolin-stimulated cAMP production treated for 30 mins by AlphaScreen assay
Agonist activity at human D2L receptor expressed in FlpIn CHO cells assessed as inhibition of forskolin-stimulated cAMP production treated for 30 mins by AlphaScreen assay
[PMID: 24827597]
CHO EC50
13.2 nM
Compound: 36
Agonist activity at human D2L receptor expressed in FlpIn CHO cells assessed as induction of ERK1/2 phosphorylation by AlphaScreen assay
Agonist activity at human D2L receptor expressed in FlpIn CHO cells assessed as induction of ERK1/2 phosphorylation by AlphaScreen assay
[PMID: 24827597]
分子量

520.52

Formula

C25H31Cl2N5OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (192.12 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9212 mL 9.6058 mL 19.2116 mL
5 mM 0.3842 mL 1.9212 mL 3.8423 mL
查看完整储备液配制表

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Dopamine D2 receptor agonist-2 相关分类

完整储备液配制表

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9212 mL 9.6058 mL 19.2116 mL 48.0289 mL
5 mM 0.3842 mL 1.9212 mL 3.8423 mL 9.6058 mL
10 mM 0.1921 mL 0.9606 mL 1.9212 mL 4.8029 mL
15 mM 0.1281 mL 0.6404 mL 1.2808 mL 3.2019 mL
20 mM 0.0961 mL 0.4803 mL 0.9606 mL 2.4014 mL
25 mM 0.0768 mL 0.3842 mL 0.7685 mL 1.9212 mL
30 mM 0.0640 mL 0.3202 mL 0.6404 mL 1.6010 mL
40 mM 0.0480 mL 0.2401 mL 0.4803 mL 1.2007 mL
50 mM 0.0384 mL 0.1921 mL 0.3842 mL 0.9606 mL
60 mM 0.0320 mL 0.1601 mL 0.3202 mL 0.8005 mL
80 mM 0.0240 mL 0.1201 mL 0.2401 mL 0.6004 mL
100 mM 0.0192 mL 0.0961 mL 0.1921 mL 0.4803 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dopamine D2 receptor agonist-21610591-93-9Dopamine ReceptorD2 receptorantipsychosisInhibitorinhibitorinhibit

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目录号：
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