2. Antibody-drug Conjugate/ADC Related
  3. Radionuclide-Drug Conjugates (RDCs)
  4. DOTA-bis(tert-butyl)ester

DOTA-bis(tert-butyl)ester 是一种 DOTA 类金属螯合剂，能够与放射性核素结合，而用于制备核素偶联物 (RDC)。DOTA-bis(tert-butyl)ester 可以与不同的盐偶联形成不同的金属螯合剂，例如与 (HY-B1244) 的盐酸盐偶联，得到 DOTA-MN2。DOTA-MN2 可与 [67]Ga-柠檬酸盐反应而获得放射性标记。当 (67)Ga-DOTA-MN2 在磷酸盐缓冲溶液或小鼠血浆中孵育 24 小时不会发生显著分解，在 NFSa 肿瘤小鼠的生物分布实验中具有高肿瘤摄取、迅速的血浆清除，是 SPECT 和 PET 研究的良好材料。

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DOTA-bis(tert-butyl)ester Chemical Structure

DOTA-bis(tert-butyl)ester Chemical Structure

CAS No. : 913542-71-9

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DOTA-bis(tert-butyl)ester 相关抗体

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RDC Peptide RDC Antibody RDC Bifunctional Chelator RDC Linker Other

  • 生物活性

  • 纯度 & 产品资料

生物活性

DOTA-bis(tert-butyl)ester is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide conjugates (RDCs). DOTA-bis(tert-butyl)ester can be conjugated with different salts to form different metal chelators, such as (HY-B1244) hydrochloride to obtain DOTA-MN2. DOTA-MN2 can be reacted with [67]Ga-citrate to obtain radiolabeling. When (67)Ga-DOTA-MN2 is incubated in phosphate buffer solution or mouse plasma for 24 hours, it does not undergo significant decomposition. In the biodistribution experiment of NFSa tumor mice, it has high tumor uptake and rapid plasma clearance, and is a good material for SPECT and PET studies.

IC50 & Target

RDC Bifunctional Chelator

 

分子量

516.63

Formula

C24H44N4O8
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

DOTA-bis(tert-butyl)ester 相关分类

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Keywords:

DOTA-bis(tert-butyl)ester913542-71-9Radionuclide-Drug Conjugates (RDCs)Inhibitorinhibitorinhibit

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