2. Protein Tyrosine Kinase/RTK
  3. FLT3 c-Kit FGFR VEGFR PDGFR
  4. Dovitinib lactate hydrate

Dovitinib lactate hydrate  (Synonyms: TKI258 lactate hydrate; CHIR-258 lactate hydrate)

目录号: HY-B0062
产品使用指南

摩尔计算器

Dovitinib lactate hydrate (TKI258 lactate hydrate) 是多靶点的酪氨酸激酶抑制剂，抑制 FLT3，c-Kit，FGFR1/3，VEGFR1/2/3 和 PDGFRα/β 的 IC50 值分别为 1，2，8/9，10/13/8，27/210 nM。

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Dovitinib lactate hydrate Chemical Structure

Dovitinib lactate hydrate Chemical Structure

CAS No. : 915769-50-5

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Dovitinib lactate hydrate 的其他形式现货产品:

Customer Review

Other Forms of Dovitinib lactate hydrate:

Dovitinib lactate hydrate 相关抗体

Top Publications Citing Use of Products

    Dovitinib lactate hydrate purchased from MCE. Usage Cited in: Front Cell Dev Biol. 2020 May 7;8:287.  [Abstract]

    Determination in L3.6 cells of FGF2-induced FGFR phosphorylation by Western blot in the presence of Dovitinib. FGFR1 and alpha-Tubulin are used as loading controls.

    Dovitinib lactate hydrate purchased from MCE. Usage Cited in: Theranostics. 2018 Jul 30;8(15):4262-4278.  [Abstract]

    BV2 cells are pretreated with 0.1% DMSO (Ctrl), JuA (25 µM) or JuA (25 µM) with the indicated antagonist of RTKs (Dovitinib at 1 µM, Gefinitib at 2.5 µM, Sunitinib at 2.5 µM and LDC1267 at 1 µM) for 30 min, followed by administration of Aβ42 (5 μM) for 12 h.

    查看 FGFR 亚型特异性产品:

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    FGFR FGFR1 FGFR2 FGFR3 FGFR4 FGF21

    查看 VEGFR 亚型特异性产品:

    查看所有亚型
    VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

    查看 PDGFR 亚型特异性产品:

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    PDGFR PDGFRβ PDGFRα

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Dovitinib lactate hydrate (TKI258 lactate hydrate) is a multi-targeted tyrosine kinase inhibitor with IC50s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, FGFR1/3, VEGFR1/2/3 and PDGFRα/β, respectively[1].

    IC50 & Target[1]

    FLT3

    1 nM (IC50)

    c-Kit

    2 nM (IC50)

    FGFR1

    8 nM (IC50)

    FGFR3

    9 nM (IC50)

    VEGFR1

    1 nM (IC50)

    VEGFR3

    8 nM (IC50)

    VEGFR2

    13 nM (IC50)

    PDGFRα

    27 nM (IC50)

    PDGFRβ

    210 nM (IC50)

    体外研究
    (In Vitro)

    Dovitinib potently inhibits the FGF-stimulated growth of WT and F384L-FGFR3-expressing B9 cells with IC50 values of 25 nM. B9-MINV cells are resistant to the inhibitory activity of Dovitinib at concentrations up to 1 μM. Dovitinib inhibits cell proliferation of KMS11 (FGFR3-Y373C), OPM2 (FGFR3-K650E), and KMS18 (FGFR3-G384D) cells with IC50 of values of 90 nM (KMS11 and OPM2) and 550 nM, respectively[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Dovitinib lactate hydrate 相关抗体:
    体内研究
    (In Vivo)

    Dovitinib (10 mg/kg, 30 mg/kg, 60 mg/kg, p.o.) shows significant antitumor effect in the KMS11-bearing mice model, and the growth inhibition is 48%, 78.5%, and 94% in the 10 mg/kg, 30 mg/kg, and 60 mg/kg treatment arms, respectively, compared with the placebo-treated mice[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    分子量

    500.52

    Formula

    C24H29FN6O5
    CAS 号
    中文名称

    多韦替尼乳酸盐水合物
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Dovitinib lactate hydrate 相关分类

    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量   浓度   体积   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Dovitinib lactate915769-50-5TKI258 lactateCHIR-258 lactate多韦替尼乳酸盐水合物FLT3c-KitFGFRVEGFRPDGFRCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3SCFRCD117Fibroblast growth factor receptorVascular endothelial growth factor receptorPlatelet-derived growth factor receptormulti-targetedtyrosinekinaseFGFR1FGFR3VEGFR1VEGFR2VEGFR3PDGFRαPDGFRβInhibitorinhibitorinhibit

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