2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. DPDPE

DPDPE 是一种阿片肽，是一种具有抗惊厥作用的选择性阿片受体 (DOR) 激动剂。

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Custom Peptide Synthesis

DPDPE Chemical Structure

DPDPE Chemical Structure

CAS No. : 88373-73-3

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规格 价格 是否有货 数量
1 mg ￥1000
In-stock
5 mg ￥2800
In-stock
10 mg   询价  
50 mg   询价  

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Customer Review

Other Forms of DPDPE:

DPDPE 相关抗体

Top Publications Citing Use of Products

查看 Opioid Receptor 亚型特异性产品:

查看所有亚型
μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DPDPE, an opioid peptide, is a selective δ-opioid receptor (DOR) agonist with anticonvulsant effects[1].

IC50 & Target

δ Opioid Receptor/DOR

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO EC50
0.12 nM
Compound: DPDPE
Agonist activity at human DOR expressed in CHO cell membranes after 60 mins by [35S]GTP-gamma-S binding assay
Agonist activity at human DOR expressed in CHO cell membranes after 60 mins by [35S]GTP-gamma-S binding assay
[PMID: 27096047]
CHO IC50
1.3 nM
Compound: DPDPE
Displacement of [3H]DADLE from human recombinant delta opioid receptor expressed in CHO cells measured after 120 mins by scintillation counting method
Displacement of [3H]DADLE from human recombinant delta opioid receptor expressed in CHO cells measured after 120 mins by scintillation counting method
[PMID: 27876250]
CHO EC50
10 nM
Compound: DPDPE
Agonist activity at mouse delta opioid receptor-1 expressed in CHO cell membranes assessed as [35S]GTPgammaS binding incubated for 60 mins by scintillation spectroscopic analysis
Agonist activity at mouse delta opioid receptor-1 expressed in CHO cell membranes assessed as [35S]GTPgammaS binding incubated for 60 mins by scintillation spectroscopic analysis
[PMID: 27556704]
CHO EC50
13.2 nM
Compound: DPDPE
Agonist activity at human delta opioid receptor over-expressed in CHO cell membrane after 1 hr by [35S]GTPgammaS binding assay
Agonist activity at human delta opioid receptor over-expressed in CHO cell membrane after 1 hr by [35S]GTPgammaS binding assay
[PMID: 26525865]
CHO EC50
8.01 nM
Compound: DPDPE
Inverse agonist activity at human DOR expressed in CHO cell membranes by [35S]GTPgammaS binding assay
Inverse agonist activity at human DOR expressed in CHO cell membranes by [35S]GTPgammaS binding assay
[PMID: 26048798]
HEK293 IC50
0.0003 μM
Compound: DPDPE
Agonist activity at human DOR expressed in HEK293 cells assessed as inhibition of forskolin-induced adenylyl cyclase-mediated cAMP accumulation after 30 mins by HTRF assay
Agonist activity at human DOR expressed in HEK293 cells assessed as inhibition of forskolin-induced adenylyl cyclase-mediated cAMP accumulation after 30 mins by HTRF assay
[PMID: 27776274]
HEK293 IC50
1.6 nM
Compound: DPDPE
Agonist activity at human MOR expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation by EIA method
Agonist activity at human MOR expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation by EIA method
[PMID: 27607020]
HEK293 IC50
1.6 nM
Compound: DPDPE
Agonist activity at human DOR expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation by EIA method
Agonist activity at human DOR expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation by EIA method
[PMID: 27607020]
体内研究
(In Vivo)

DPDPE (70 or 140 nM; i.c.v.; once) shows anticonvulsant effects in rats[1].
DPDPE (0.78–25 μg/mouse; i.c.v.; once) enhances bicuculline-induced convulsions in mouse[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (225-275 g)[1]
Dosage: 70 or 140 nM followed by a 2 μl saline flush
Administration: Intracerebroventricular injection
Result: Resulted in a significant, dose-dependent increase in the convulsive threshold to flurothyl.
Animal Model: Male ddY mice weighing 20–30 g, pretreated with 1.5 mg/kg bicuculline (subcutaneous injection)[2].
Dosage: 0.78–25 μg/mouse, once
Administration: Intracerebroventricular injection
Result: Caused a dose-dependent increase in the proportion of mice exhibiting convulsions.
分子量

645.79

Formula

C30H39N5O7S2
CAS 号
性状

固体

颜色

White to off-white

Sequence

Tyr-{Pen}-Gly-Phe-{Pen} (Disulfide bridge:Pen2-Pen5)
Sequence Shortening

Y{Pen}GF{Pen} (Disulfide bridge:Pen2-Pen5)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 10 mg/mL (15.48 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5485 mL 7.7425 mL 15.4849 mL
5 mM 0.3097 mL 1.5485 mL 3.0970 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

DPDPE 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.5485 mL 7.7425 mL 15.4849 mL 38.7123 mL
5 mM 0.3097 mL 1.5485 mL 3.0970 mL 7.7425 mL
10 mM 0.1548 mL 0.7742 mL 1.5485 mL 3.8712 mL
15 mM 0.1032 mL 0.5162 mL 1.0323 mL 2.5808 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DPDPE88373-73-3Opioid Receptoranticonvulsant effectsInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-P1334
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