2. GPCR/G Protein MAPK/ERK Pathway Apoptosis
  3. Apoptosis Ras Raf Caspase
  4. DPQZ

DPQZ 是一种抑制细胞分离的抗微管蛋白剂，可诱导细胞周期阻滞在 G2/M 期。此外，DPQZ 通过抑制 Ras/Raf 并激活 MAP 激酶 (MAP kinase) 诱导 caspase 依赖性 HSC-3 细胞凋亡 (apoptosis)。DPQZ 可用于口腔癌的研究。

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DPQZ Chemical Structure

DPQZ Chemical Structure

CAS No. : 1431362-93-4

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DPQZ 相关抗体

Top Publications Citing Use of Products

查看 Ras 亚型特异性产品:

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K-Ras H-Ras N-Ras Ras

查看 Raf 亚型特异性产品:

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BRaf c-Raf Raf

查看 Caspase 亚型特异性产品:

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DPQZ is an anti-tubulin agent that inhibits cell separation and induces cell cycle arrest at the G2/M phase. In addition, DPQZ induces caspase-dependent apoptosis of HSC-3 cells by inhibiting Ras/Raf and activating MAP kinase. DPQZ can be used in the study of oral cancer[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-15 IC50
0.46 μM
Compound: 14
Cytotoxicity against human HCT15 cells measured after 2 days by MTT assay
Cytotoxicity against human HCT15 cells measured after 2 days by MTT assay
[PMID: 26334499]
HeLa IC50
0.05 μM
Compound: 14
Cytotoxicity against human HeLa cells measured after 2 days by MTT assay
Cytotoxicity against human HeLa cells measured after 2 days by MTT assay
[PMID: 26334499]
T47D IC50
> 50 μM
Compound: 14
Cytotoxicity against human T47D cells measured after 2 days by MTT assay
Cytotoxicity against human T47D cells measured after 2 days by MTT assay
[PMID: 26334499]
分子量

315.37

Formula

C20H17N3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DPQZ 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DPQZ1431362-93-4ApoptosisRasRafCaspaseRaf kinasesTubulincell cycleapoptosisHSC-3 cellsoral cancerInhibitorinhibitorinhibit

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