2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Antibody-drug Conjugate/ADC Related Apoptosis
  3. PERK Antibody-Drug Conjugates (ADCs) HSP Eukaryotic Initiation Factor (eIF) Apoptosis
  4. DTX-P7

DTX-P7 是一种多肽药物偶联物 (PDC)。DTX-P7，由Docetaxel (DTX, HY-B0011) 和一个七肽（P7）组成，通过降解 Hsp90 来诱导未折叠蛋白反应和随后的细胞凋亡。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Custom Peptide Synthesis

DTX-P7 Chemical Structure

DTX-P7 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

DTX-P7 相关抗体

Top Publications Citing Use of Products

查看 HSP 亚型特异性产品:

查看所有亚型
HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DTX-P7 is a peptide-drug conjugate. DTX-P7, composed of Docetaxel (DTX, HY-B0011) and a heptapeptide (P7), induces unfolded protein response and subsequent apoptosis by degrading Hsp90[1].
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
11.4 nM
PMID: 35659720
H1975 IC50
0.62 nM
PMID: 35659720
体外研究
(In Vitro)

DTX-P7 以剂量和时间依赖的方式抑制膜上 Hsp90 的表达，而mRNA水平没有观察到变化[1]。
DTX-P7 增强了PERK 和 eIF2α 的磷酸化，但在 A549 细胞暴露时没有观察到 XBP-1 mRNA 剪接[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DTX-P7 相关抗体:
体内研究
(In Vivo)

DTX-P7 (mice implanted with A549 xenograft tumor, 15/30 mg/kg, once a week for 4 weeks) 通过降解 DYRK1A 并随后使细胞周期重新进入，抑制了休眠/缓慢增殖的 A549/CD133 + 细胞的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1639.87

Formula

C84H118N8O25
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DTX-P7 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DTX-P7PERKAntibody-Drug Conjugates (ADCs)HSPEukaryotic Initiation Factor (eIF)ApoptosisProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinaseAntibody-Drug ConjugatesHeat shock proteinsA549NSCLCCSLCHsp90Non-small cell lung cancerHeat shock protein 90 (Hsp90)Cancer stem-like cells (CSLCs)Cell cycle reentryDormancyTargeting deliveryUnfolded protein responseInhibitorinhibitorinhibit

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目录号：
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