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  4. (E)-5-(2-Bromovinyl)pyrimidine-2,4(1H,3H)-dione

(E)-5-(2-Bromovinyl)pyrimidine-2,4(1H,3H)-dione  (Synonyms: (E)-5-(2-Bromovinyl)uracil; BVU)

目录号: HY-W014109
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(E)-5-(2-Bromovinyl)pyrimidine-2,4(1H,3H)-dione ((E)-5-(2-Bromovinyl)uracil; BVU) 是一种嘧啶碱基，是抗病毒药物索利夫定和 (E)-5-(2-溴乙烯基)-2'-脱氧尿苷 (BVDU) 的无活性代谢物，可在体内再生为 BVDU。BVU 以 NADPH 依赖的方式不可逆地灭活二氢嘧啶脱氢酶 (DPD)。1,4 当以 200 μmol/kg 的剂量给药时，它可以增强化疗药物和 DPD 底物 5-氟尿嘧啶 (HY-90006) 在 P388 鼠白血病模型中的疗效，从而延长生存时间。

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(E)-5-(2-Bromovinyl)pyrimidine-2,4(1H,3H)-dione Chemical Structure

(E)-5-(2-Bromovinyl)pyrimidine-2,4(1H,3H)-dione Chemical Structure

CAS No. : 69304-49-0

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(E)-5-(2-Bromovinyl)pyrimidine-2,4(1H,3H)-dione 相关抗体

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生物活性

(E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner. It enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil (HY-90006) in a P388 murine leukemia model when administered at a dose of 200 μmol/kg, increasing survival time.

分子量

217.02

Formula

C6H5BrN2O2
CAS 号
中文名称

(E)-5-(2-溴乙烯基)嘧啶-2,4(1H,3H)-二酮
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(E)-5-(2-Bromovinyl)pyrimidine-2,4(1H,3H)-dione 相关分类

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Keywords:

(E)-5-(2-Bromovinyl)pyrimidine-2,4(1H,3H)-dione69304-49-0(E)-5-(2-Bromovinyl)uracil BVU(E)-5-(2-溴乙烯基)嘧啶-2,4(1H,3H)-二酮OthersInhibitorinhibitorinhibit

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