(E/Z)-Xanthohumol

目录号: HY-N1067A: FAQs
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(E/Z)-Xanthohumol 是一种从啤酒花中分离出来的黄酮类化合物。

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(E/Z)-Xanthohumol Chemical Structure

CAS No. : 569-83-5

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生物活性
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参考文献

生物活性

(E/Z)-Xanthohumol is a flavonoid isolated from hopfen^[1].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A549	IC₅₀	11.9 μM Compound: Xn	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 30196062]
A549	IC₅₀	30.5 μM Compound: 8a, Xn	Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay	[PMID: 25629304]
BGC-823	IC₅₀	7.8 μM Compound: Xanthohumol	Cytotoxicity against human BGC823 cells assessed as cell growth inhibition after 72 hrs by MTT assay Cytotoxicity against human BGC823 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 29288946]
BV-2	IC₅₀	7.92 μM Compound: 14	Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by griess assay Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by griess assay	[PMID: 29154541]
HEK293	IC₅₀	35 μM Compound: 1	Inhibition of TNF-alpha-induced NF-kappaB activation expressed in human HEK293 cells preincubated for 2 hrs before TNFalpha challenge by leuciferase reporter gene assay Inhibition of TNF-alpha-induced NF-kappaB activation expressed in human HEK293 cells preincubated for 2 hrs before TNFalpha challenge by leuciferase reporter gene assay	[PMID: 19757857]
HeLa	IC₅₀	> 40 μM Compound: 8a, Xn	Inhibition of TrxR in human HeLa cells assessed as depletion of cellular thiol after 48 hrs Inhibition of TrxR in human HeLa cells assessed as depletion of cellular thiol after 48 hrs	[PMID: 25629304]
HeLa	IC₅₀	40.4 μM Compound: 8a, Xn	Cytotoxicity against human HeLa cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay	[PMID: 25629304]
HeLa	IC₅₀	9.4 μM Compound: 7	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	[PMID: 20153559]
HeLa	IC₅₀	9.4 μM Compound: 1, xanthohumol	Cytotoxicity against human HeLa cells by MTT assay Cytotoxicity against human HeLa cells by MTT assay	[PMID: 18343123]
HeLa	IC₅₀	9.4 μM Compound: 1	Cytotoxicity against human HeLa cells by MTT assay after 72 hrs Cytotoxicity against human HeLa cells by MTT assay after 72 hrs	[PMID: 18611049]
HepG2	IC₅₀	35 μM Compound: 8a, Xn	Cytotoxicity against human HepG2 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay	[PMID: 25629304]
HMEC-1	IC₅₀	11.4 μM Compound: Xanthohumol	Antiangiogenic activity in SV-40T transfected human HMEC1 cells assessed as inhibition of cell proliferation after 72 hrs by crystal violet staining Antiangiogenic activity in SV-40T transfected human HMEC1 cells assessed as inhibition of cell proliferation after 72 hrs by crystal violet staining	[PMID: 23030826]
HMEC-1	IC₅₀	11.4 μM Compound: Xanthohumol	Antiproliferative activity against human HMEC1 cells after 72 hrs Antiproliferative activity against human HMEC1 cells after 72 hrs	[PMID: 25128665]
HT-29	IC₅₀	91.31 μM Compound: 1, Xanthohumol	Antiproliferative activity against human HT-29 cells after 72 hrs by SRB assay Antiproliferative activity against human HT-29 cells after 72 hrs by SRB assay	[PMID: 23466227]
HT-29	IC₅₀	91.31 μM Compound: 1	Cytotoxicity against human HT-29 cells after 72 hrs by SRB assay Cytotoxicity against human HT-29 cells after 72 hrs by SRB assay	[PMID: 23434138]
Ishikawa	IC₅₀	4.2 μM Compound: XH	Cytotoxicity against human Ishikawa cells after 96 hrs by SRB assay Cytotoxicity against human Ishikawa cells after 96 hrs by SRB assay	[PMID: 28812892]
MCF7	IC₅₀	10.95 μM Compound: 1, Xanthohumol	Antiproliferative activity against human MCF7 cells after 72 hrs by SRB assay Antiproliferative activity against human MCF7 cells after 72 hrs by SRB assay	[PMID: 23466227]
MCF7	IC₅₀	10.95 μM Compound: 1	Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay	[PMID: 23434138]
MCF7	IC₅₀	13.3 μM Compound: Xanthohumol	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 2 days by SRB assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 2 days by SRB assay	[PMID: 33257172]
MCF7	IC₅₀	3.47 μM Compound: Xanthohumol	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 4 days by SRB assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 4 days by SRB assay	[PMID: 33257172]
NCI-H1975	IC₅₀	13 μM Compound: Xn	Antiproliferative activity against human NCI-H1975 cells after 72 hrs by MTT assay Antiproliferative activity against human NCI-H1975 cells after 72 hrs by MTT assay	[PMID: 30196062]
NCI-H460	IC₅₀	6.9 μM Compound: Xanthohumol	Cytotoxicity against human NCI-H460 cells assessed as cell growth inhibition after 72 hrs by MTT assay Cytotoxicity against human NCI-H460 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 29288946]
NCI-H460	IC₅₀	7.5 μM Compound: Xn	Antiproliferative activity against human NCI-H460 cells after 72 hrs by MTT assay Antiproliferative activity against human NCI-H460 cells after 72 hrs by MTT assay	[PMID: 30196062]
PC-3	IC₅₀	10.67 μM Compound: 1, Xanthohumol	Antiproliferative activity against human PC3 cells after 72 hrs by SRB assay Antiproliferative activity against human PC3 cells after 72 hrs by SRB assay	[PMID: 23466227]
PC-3	IC₅₀	10.67 μM Compound: 1	Cytotoxicity against human PC3 cells after 72 hrs by SRB assay Cytotoxicity against human PC3 cells after 72 hrs by SRB assay	[PMID: 23434138]
RAW264.7	IC₅₀	8.3 μM Compound: 1	Inhibition of LPS/IFN-gamma-induced NO production in mouse RAW264.7 cells after 16 hrs Inhibition of LPS/IFN-gamma-induced NO production in mouse RAW264.7 cells after 16 hrs	[PMID: 15679315]
SGC-7901	IC₅₀	10 μM Compound: Xanthohumol	Cytotoxicity against human SGC7901 cells assessed as cell growth inhibition after 72 hrs by MTT assay Cytotoxicity against human SGC7901 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 29288946]
VSMC	IC₅₀	3.49 μM Compound: 1	Inhibition of PDGF-BB-induced rat VSMC proliferation preincubated for 30 mins followed by PDGF-BB addition measured after 48 hrs by resazurin assay Inhibition of PDGF-BB-induced rat VSMC proliferation preincubated for 30 mins followed by PDGF-BB addition measured after 48 hrs by resazurin assay	[PMID: 28627872]

分子量

354.40

Formula

C₂₁H₂₂O₅

CAS 号

569-83-5

结构分类

初始来源

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

产品使用指南 (1538 KB)

参考文献

[1]. Rudolf Hänsel, et al. Desmethylxanthohumol: Isolierung aus Hopfen und Cyclisierung zu Flavanonen. Arch. Der Pharm.1988, 321, 1.

(E/Z)-Xanthohumol 相关分类

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摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E/Z)-Xanthohumol569-83-5OthersNature ProductsInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

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上海工商

沪公网安备31011502019417

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营业执照（三证合一）

(E/Z)-Xanthohumol

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