2. Protein Tyrosine Kinase/RTK
  3. FGFR
  4. Efruxifermin

Efruxifermin 

目录号: HY-P99930 纯度: 98.32%
COA

摩尔计算器

Efruxifermin 是一种 Fc-FGF21 融合蛋白(人 IgG1 Fc 结构域连接到修饰的人 FGF21)。与天然人 FGF21 相比，Efruxifermin 的半衰期延长，受体亲和力增强。Efruxifermin 可用于非酒精性脂肪性肝炎的研究。

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CAS No. : 2375240-92-7

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规格 价格 是否有货 数量
1 mg ￥6500
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Efruxifermin 相关抗体

Top Publications Citing Use of Products

查看 FGFR 亚型特异性产品:

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FGFR FGFR1 FGFR2 FGFR3 FGFR4 FGF21

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Efruxifermin is an Fc-FGF21 fusion protein (human IgG1 Fc domain linked to a modified human FGF21). Efruxifermin has prolonged half-life and enhanced receptor affinity compared with native human FGF21. Efruxifermin can be used for the research of non-alcoholic steatohepatitis[1].

同型

IGHG1 Fc (Fragment constant)-[FGF21 (fibroblast growth factor 21)]2
种属

Human
IC50 & Target

FGF21

 

体内研究
(In Vivo)

Efruxifermin (0-100 mg/kg, SC, Once weekly, for 4 or 26?weeks) reduces body weight gain of Sprague Dawley rats in a dose-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male and female Sprague Dawley rats[1]
Dosage: 0, 1, 10, 30, 100 mg/kg
Administration: Subcutaneous injection, Once weekly, for 4 or 26 weeks
Result: Significantly reduced body weight gain after 4 and 26 weeks, despite increasing food intake. Markers of sympathetic activation, urinary corticosterone and ratio of adrenal-to-body weight were unchanged.
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • IGHG1 Fc (Fragment constant)-[FGF21 (fibroblast growth factor 21)]2
纯度 & 产品资料

纯度: 98.32%

COA (264 KB) SDS-PAGE (82 KB) SEC-HPLC (137 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Efruxifermin 相关分类

  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Efruxifermin2375240-92-7FGFRFibroblast growth factor receptorInhibitorinhibitorinhibit

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目录号：
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