2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. EGFR/HER2-IN-7

EGFR/HER2-IN-7 是一种强效抗癌剂，对癌细胞具有高选择性，特异作用于乳腺癌细胞 MCF-7。EGFR/HER2-IN-7 是一种 EGFR/HER2 激酶抑制剂，IC50 分别为 0.18 μM (EGFR)， 0.146 μM (HER2)。EGFR/HER2-IN-7 中等抑制 DHFR，IC50 为 0.907 μM。

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EGFR/HER2-IN-7 Chemical Structure

EGFR/HER2-IN-7 Chemical Structure

CAS No. : 2820126-28-9

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EGFR/HER2-IN-7 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR/HER2-IN-7 is a potent anticancer agent with high selectivity against MCF-7 breast cancer cells. EGFR/HER2-IN-7 is a EGFR/HER2 kinase and DHFR inhibitor, with IC50s of 0.18 μM (EGFR), 0.146 μM (HER2), respectively. EGFR/HER2-IN-7 shows moderate inhibition on DHFR (IC50=0.907 μM)[1].

IC50 & Target

0.18 μM (EGFR); 0.146 μM (HER2); 0.907 μM (DHFR)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 IC50
13.78 μM
Compound: 27
Antiproliferative activity against human HCT-116 cells after 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells after 72 hrs by MTT assay
[PMID: 35964425]
HeLa IC50
7.63 μM
Compound: 27
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
[PMID: 35964425]
HepG2 IC50
10.81 μM
Compound: 27
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
[PMID: 35964425]
MCF7 IC50
8.29 μM
Compound: 27
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 35964425]
PC-3 IC50
16.63 μM
Compound: 27
Antiproliferative activity against human PC-3 cells after 72 hrs by MTT assay
Antiproliferative activity against human PC-3 cells after 72 hrs by MTT assay
[PMID: 35964425]
WI-38 IC50
> 100 μM
Compound: 27
Antiproliferative activity against human WI-38 cells after 72 hrs by MTT assay
Antiproliferative activity against human WI-38 cells after 72 hrs by MTT assay
[PMID: 35964425]
体外研究
(In Vitro)

EGFR/HER2-IN-7 (compound 27) shows remarkable broad spectrum cytotoxic potency, with an IC50 value of 10.81 μM against MCF-7 breast cancer cells[1].
EGFR/HER2-IN-7 (72 h) displays anti-breast cancer activity with an IC50 value of 8.29 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

EGFR/HER2-IN-7 相关抗体:

Cell Viability Assay[1]

Cell Line: HepG2 hepatocellular carcinoma, MCF-7 breast cancer, HCT-116 colorectal carcinoma, PC-3 prostate and Hea cervical epithelioid carcinoma
Concentration: 0-1 mM
Incubation Time: 72 hours
Result: Inhibited cancer cells growth with IC50s of 10.81 μM (HepG2), 8.29 μM (MCF-7), 13.78 μM (HCT-116), 16.63 μM (PC3), 7.63 μM (Hela), respectively.

Cell Cytotoxicity Assay[1]

Cell Line: Normal healthy cell line WI-38 (fetal lung fibroblast cells)
Concentration: 0-1 mM
Incubation Time: 72 hours
Result: Showed low cytotoxicity against healthy cells with high IC50s of >100 μM, 67.2 μM, 54.18, 89.61 μM, 36.84 μM, 49.75 μM, respectively.
分子量

355.45

Formula

C19H21N3O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EGFR/HER2-IN-7 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR/HER2-IN-72820126-28-9EGFREpidermal growth factor receptorErbB-1HER1thiazole Imidazo[2,1-b]thiazolein vivo?anti-breast cancer assaypharmacophore predictionInhibitorinhibitorinhibit

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