2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Apoptosis
  3. EGFR Apoptosis
  4. EGFR-IN-108 chloride

EGFR-IN-108 chloride (Compound Ru3S) 是一种 EGFR 抑制剂，对 hEGFR 的 IC50 值为 5.8 nM。EGFR-IN-108 chloride 可诱导细胞凋亡 (apoptosis) ，对癌细胞具有抗增殖活性。EGFR-IN-108 chloride 还具有抗血管生成作用。

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EGFR-IN-108 chloride Chemical Structure

EGFR-IN-108 chloride Chemical Structure

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EGFR-IN-108 chloride 相关抗体

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR-IN-108 chloride (Compound Ru3S) is an EGFR inhibitor with an IC50 value of 5.8 nM for hEGFR. EGFR-IN-108 chloride induces apoptosis and has anti-proliferative activity against cancer cells. EGFR-IN-108 chloride also has anti-angiogenic effects[1].

体外研究
(In Vitro)

Ru4S (0.2-100 μM; 48 h) 对 HepG2, Caco-2, HT-29, MCF-7, A549, HEK293T 细胞系具有细胞毒性，IC50 值分别为 23.76, 2.47, 6.24, 5.35, 29.90, 33.15 μM[1]。
Ru4S (0.78-50 μM; 48 h) 诱导 HepG2 细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

EGFR-IN-108 chloride 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: HepG2, Caco-2, HT-29, MCF-7, A549, HEK293T cells
Concentration: 0.2-100 μM
Incubation Time: 48 h
Result: exhibited cytotoxicity.

Cell Proliferation Assay[1]

Cell Line: HepG2 cells
Concentration: 0.78, 3.12, 12.5, and 50 μM
Incubation Time: 48 h
Result: increased Sub G1 (p < 0.0001) and decreased G0/G1, S, and G2/M percentages (p < 0.05) at 0.78 μM. And slightly increased Sub G1 (p < 0.01), slightly decreased G0/G1 (p < 0.01), and decreased G2/M (p < 0.05) at 3.12 and 12.5 μM. Increased Sub G1(p < 0.0001) and decreased S (p < 0.01), and did not affect the G0/G1 and G2/M phases at 50 μM.
分子量

1005.28

Formula

C45H40Cl3F3N8O3Ru
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EGFR-IN-108 chloride 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-108EGFRApoptosisEpidermal growth factor receptorErbB-1HER1HepG2 cellsCaco-2 cellsHT-29 cellsMCF-7 cellscytotoxicitycell cycleInhibitorinhibitorinhibit

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产品名称：
EGFR-IN-108 chloride
目录号：
HY-163402
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