2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Cell Cycle/DNA Damage Cytoskeleton Immunology/Inflammation Apoptosis
  3. EGFR Microtubule/Tubulin Interleukin Related TNF Receptor Apoptosis
  4. EGFR-IN-144

EGFR-IN-144 (Compound 4B) 对 EGFR (IC50=0.639 µg/mL) 和微管蛋白聚合 (tubulin polymerization，IC50=7.339 µg/mL) 表现出抑制活性。EGFR-IN-144 在多种癌细胞中表现出细胞毒性，GI50 为纳摩尔水平。EGFR-IN-144 下调 mTOR、TNF-α 和 IL-6 的表达，在 G1/S 期阻滞细胞周期，并诱导细胞凋亡 (apoptosis)。

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EGFR-IN-144 Chemical Structure

EGFR-IN-144 Chemical Structure

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EGFR-IN-144 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

查看 Interleukin Related 亚型特异性产品:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR-IN-144 (Compound 4B) exhibits inhibitory activities against EGFR (IC50=0.639 µg/mL) and tubulin polymerization (IC50=7.339 µg/mL). EGFR-IN-144 exhibits cytotoxicity in multiple cancer cell with GI50 of nanomolare levels. EGFR-IN-144 downregulates the expressions of mTOR, TNF-α, and IL-6, arrests the cell cycle at G1/S phase, and induces apoptosis[1].

分子量

418.27

Formula

C20H17Cl2N3O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EGFR-IN-144 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-144EGFRMicrotubule/TubulinInterleukin RelatedTNF ReceptorApoptosisEpidermal growth factor receptorErbB-1HER1ILTumor Necrosis Factor ReceptorTNFRMelanomacolorectal cancerHCT-116Inhibitorinhibitorinhibit

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产品名称：
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HY-172111
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