2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Apoptosis
  3. EGFR Apoptosis
  4. EGFR-IN-59

EGFR-IN-59 (Compound 8c) 是一种 EGFR 抑制剂 (IC50=190 nM) 和凋亡 (apoptosis) 诱导剂。EGFR-IN-59 对非小肺癌细胞系 (A549) 和正常肺成纤维细胞 (WI38) 具有细胞毒性，IC50 分别为 8.62 和 52.6 µM。EGFR-IN-59可用于非小细胞肺癌 (NSCLC)、头颈癌、乳腺癌和结直肠癌等多种癌症的研究。

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EGFR-IN-59 Chemical Structure

EGFR-IN-59 Chemical Structure

CAS No. : 2529891-44-7

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EGFR-IN-59 相关抗体

Top Publications Citing Use of Products

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 参考文献

生物活性

EGFR-IN-59 (Compound 8c) is a EGFR inhibitor (IC50=190 nM) and apoptosis inducer. EGFR-IN-59 exhibits cytotoxicity against non-small lung cancer cell lines (A549) and normal lung fibroblasts (WI38) with IC50s of 8.62 and 52.6 µM, respectively. EGFR-IN-59 can be used for the research of various cancers such as non-small cell lung cancer (NSCLC), head and neck cancer, breast cancer and colorectal cancer[1].

体外研究
(In Vitro)

EGFR-IN-59 (Compound 8c; 0-65.5 µM; 48 hours) shows cytotoxicity against non-small lung cancer cell lines (A549) and normal lung fibroblasts (WI38) [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

EGFR-IN-59 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: A549; WI38 cells
Concentration: 0-65.5 µM
Incubation Time: 48 hours
Result: Showed potent cytotoxicity against A549 cell line (IC50=8.62 µM), and mild to moderate toxicity against WI38 (IC50=52.6 µM).
分子量

513.57

Formula

C27H23N5O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

EGFR-IN-59 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

EGFR-IN-592529891-44-7EGFRApoptosisEpidermal growth factor receptorErbB-1HER1apoptosisA549normal lung fibroblastsWI38non-small cell lung cancerNSCLChead and neck cancerbreast cancer and colorectal cancerAntitumorEGFR inhibitionInhibitorinhibitorinhibit

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