2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. EGFR-IN-71

EGFR-IN-71 是一种有效的窄谱表皮生长因子受体 (EGFR) 抑制剂，IC50 为 3.7 μM。EGFR-IN-71 可用于脊索瘤的研究。EGFR-IN-71 是一种点击化学试剂。它含有 Alkyne 基团，可以和含有 Azide 基团的分子发生铜催化的叠氮-炔环加成反应 (CuAAc)。

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EGFR-IN-71 Chemical Structure

EGFR-IN-71 Chemical Structure

CAS No. : 2676155-98-7

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EGFR-IN-71 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR-IN-71 is a potent narrow spectrum epidermal growth factor receptor (EGFR) inhibitor with IC50 values of 3.7 μM. EGFR-IN-71 can be used for researching chordoma[1]. EGFR-IN-71 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

IC50: 3.7 μM (EGFR)[1]
体外研究
(In Vitro)

EGFR-IN-71 (compound 41) (0-100 μM; 72 h) has inhibitory activity against U-CH1, U-CH2, CH22, UM-Chor1, U-CH12 and U-CH7 chordoma cell lines[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

EGFR-IN-71 相关抗体:

Cell Viability Assay[1]

Cell Line: U-CH1, U-CH2, CH22, UM-Chor1, U-CH12 and U-CH7
Concentration: 0-100 μM
Incubation Time: 72 h
Result: Exhibited inhibitory activity against U-CH1, U-CH2, CH22, UM-Chor1, U-CH12 and U-CH7 chordoma cell lines with IC50s of 9.1 μM, 16 μM, 0.48 μM, 25 μM, 0.96 μM and 8.0 μM, respectively.
分子量

405.62

Formula

C16H9ClIN3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EGFR-IN-71 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-712676155-98-7EGFREpidermal growth factor receptorErbB-1HER1ChordomaU-CH1U-CH2CH22UM-Chor1U-CH12U-CH7Inhibitorinhibitorinhibit

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产品名称：
EGFR-IN-71
目录号：
HY-150781
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