2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. EGFR kinase inhibitor 4

EGFR kinase inhibitor 4 (Compound 4) 是一种二价 ATP 变构 EGFR 抑制剂 (对于突变 EGFR (LRTMCS) IC50 为 1.8 nM) 。EGFR kinase inhibitor 4 可用于非小细胞肺癌 (NSCLC) 的研究。

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EGFR kinase inhibitor 4 Chemical Structure

EGFR kinase inhibitor 4 Chemical Structure

CAS No. : 2922402-05-7

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EGFR kinase inhibitor 4 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EGFR kinase inhibitor 4 (Compound 4) is a bivalent ATP-allosteric EGFR inhibitor (IC50: 1.8 nM for mutant EGFR (LRTMCS)). EGFR kinase inhibitor 4 can be used for research of NSCLC[1].
IC50 & Target

IC50: 1.8 nM for mutant EGFR (LRTMCS)[1]
体外研究
(In Vitro)

EGFR kinase inhibitor 4 (0-10 μM，6 小时) 抑制人 NSCLC 细胞系 (H1975、H3255、HCC827 细胞) 中的 LRTM 磷酸化 (pY1068) 以及下游 pERK 和 pAKT[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

EGFR kinase inhibitor 4 相关抗体:
分子量

690.75

Formula

C40H34N8O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EGFR kinase inhibitor 4 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR kinase inhibitor 42922402-05-7EGFR kinase inhibitor4EGFR kinase inhibitor-4EGFREpidermal growth factor receptorErbB-1HER1NSCLCbivalentATP-allostericInhibitorinhibitorinhibit

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