1. 天然产物
  2. 疾病研究领域 植物 醌类 酚类
  3. 蓼科 炎症/免疫 蒽醌类 多酚类
  4. 虎杖
  5. Emodin 6-O-β-D-glucoside

Emodin 6-O-β-D-glucoside  (Synonyms: Glucoemodin)

目录号: HY-N8126 纯度: 98.00%
COA 产品使用指南

Emodin-6-O-β-D-glucoside (Glucoemodin) 是从 虎杖中提取的一种活性化合物。Emodin-6-O-β-D-glucoside 具有明显的抗炎和屏障保护作用。Emodin-6-O-β-D-glucoside 可用于糖尿病并发症和动脉粥样硬化的研究。

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Emodin 6-O-β-D-glucoside Chemical Structure

Emodin 6-O-β-D-glucoside Chemical Structure

CAS No. : 34298-85-6

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5 mg ¥2200
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10 mg ¥3500
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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Emodin-6-O-β-D-glucoside (Glucoemodin) is an active compound from Reynoutria japonica. Emodin-6-O-β-D-glucoside shows potent anti-inflammatory and barrier protective effects. Emodin-6-O-β-D-glucoside can be used for the research of diabetic complications and atherosclerosis[1].

体外研究
(In Vitro)

Emodin-6-O-β-D-glucoside (0~20 μM; 24 hours; HUVECs) does not affect cell viability[1].
Emodin-6-O-β-D-glucoside (0~10 μM; 6 hours; HUVECs) results in a dose dependent decrease in high glucose-mediated membrane disruption, inhibits high glucose-induced increase expression of VCAM-1, ICAM-1 and E-selectin and results in decreased expression levels of high glucose-induced MCP-1 and IL-8 mRNA[1].
Emodin-6-O-β-D-glucoside (10 μM; 6 hours; HUVECs) results in a decrease in the number of THP-1 cells adhering to high glucose-induced HUVECs[1].
Emodin-6-O-β-D-glucoside pretreatment significantly inhibits high-glucose-induced ROS formation and p65 NF-κB expression levels increase[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HUVECs
Concentration: 0~20 μM
Incubation Time: 24 hours
Result: Did not affect cell viability.

Western Blot Analysis[1]

Cell Line: HUVECs
Concentration: 0~10 μM
Incubation Time: 6 hours
Result: Inhibited high glucose-induced increase expression of VCAM-1, ICAM-1 and E-selectin.

RT-PCR[1]

Cell Line: HUVECs
Concentration: 0~10 μM
Incubation Time: 6 hours
Result: Resulted in decreased expression levels of high glucose-induced MCP-1 and IL-8 mRNA.

Immunofluorescence[1]

Cell Line: HUVECs
Concentration: 10 μM
Incubation Time: 6 hours
Result: Resulted in a decrease in the number of THP-1 cells adhering to high glucose-induced HUVECs.
体内研究
(In Vivo)

Emodin-6-O-β-D-glucoside (0~9 mg/mouse; i.v.) markly inhibits peritoneal leakage of dye induced by high glucose[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse[1]
Dosage: 0~9 mg/mouse
Administration: I.v.
Result: Markly inhibited peritoneal leakage of dye induced by high glucose.
分子量

432.38

Formula

C21H20O10

CAS 号
性状

固体

颜色

Light yellow to yellow

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验: 

DMSO 中的溶解度 : 100 mg/mL (231.28 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.3128 mL 11.5639 mL 23.1278 mL
5 mM 0.4626 mL 2.3128 mL 4.6256 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3128 mL 11.5639 mL 23.1278 mL 57.8195 mL
5 mM 0.4626 mL 2.3128 mL 4.6256 mL 11.5639 mL
10 mM 0.2313 mL 1.1564 mL 2.3128 mL 5.7820 mL
15 mM 0.1542 mL 0.7709 mL 1.5419 mL 3.8546 mL
20 mM 0.1156 mL 0.5782 mL 1.1564 mL 2.8910 mL
25 mM 0.0925 mL 0.4626 mL 0.9251 mL 2.3128 mL
30 mM 0.0771 mL 0.3855 mL 0.7709 mL 1.9273 mL
40 mM 0.0578 mL 0.2891 mL 0.5782 mL 1.4455 mL
50 mM 0.0463 mL 0.2313 mL 0.4626 mL 1.1564 mL
60 mM 0.0385 mL 0.1927 mL 0.3855 mL 0.9637 mL
80 mM 0.0289 mL 0.1445 mL 0.2891 mL 0.7227 mL
100 mM 0.0231 mL 0.1156 mL 0.2313 mL 0.5782 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Emodin 6-O-β-D-glucoside
目录号:
HY-N8126
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