2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. Enpp-1-IN-11

Enpp-1-IN-11 (compound 23) 是一种有效的外核苷酸焦磷酸酶-磷酸二酯酶 1 (ENPP1) 抑制剂，Ki 为 45 nM。Enpp-1-IN-11 在人和小鼠肝脏微粒体中的清除能力较低，在人和小鼠血浆中具有良好的血浆稳定性。Enpp-1-IN-11 可用于抗癌研究。

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Enpp-1-IN-11 Chemical Structure

Enpp-1-IN-11 Chemical Structure

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Enpp-1-IN-11 相关抗体

Top Publications Citing Use of Products

查看 Phosphodiesterase (PDE) 亚型特异性产品:

查看所有亚型
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Enpp-1-IN-11 (compound 23) is a potent Ecto-nucleotide pyrophosphatase/phosphodiesterases 1 (ENPP1) inhibitor with an Ki value of 45 nM. Enpp-1-IN-11 exhibits low clearance in human and mouse liver microsomes, good plasma stability in human and mouse plasma. Enpp-1-IN-11 can be used for researching anticancer[1].

IC50 & Target

Ki: 45 nM (ENPP1)[1]
体内研究
(In Vivo)

Enpp-1-IN-11 has low clearance in human and mouse liver microsomes, good plasma stability in human and mouse plasma[1].
Pharmacokinetic Parameters of Enpp-1-IN-11 in female BALB/c mice[1].

PO (10 mg/kg) IV (1 mg/kg)
Tmax (h) 1.2
Cmax (ng/mL) 33.10 1600.20
C0 (ng/mL) 4546.51
Tmax (h) 0.50 0.08
AUClast (ng/mL·h) 29.47 404.40
AUCinf (ng/mL·h) 31.78 415.55
AUCextrap (%) 7.26 2.68
t1/2 (h) 0.54 0.11
MRTlast (h) 0.66 0.07
CL (mL/min/kg) 40.10
VSS (L/kg) 0.22
F (%) <1

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

345.38

Formula

C15H15N5O3S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Enpp-1-IN-11 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Enpp-1-IN-11Phosphodiesterase (PDE)ENPP1low clearanceplasma stabilityanticancerInhibitorinhibitorinhibit

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目录号：
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