2. Protein Tyrosine Kinase/RTK
  3. Ephrin Receptor
  4. EphA2 agonist 1

EphA2 agonist 1 (Compound 7bg) 是一种有效的 EphA2 receptor 激动剂。EphA2 agonist 1 对 EphA2 过表达的胶质瘤细胞具有很强的活性和选择性，并能刺激EphA2磷酸化。

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EphA2 agonist 1 Chemical Structure

EphA2 agonist 1 Chemical Structure

CAS No. : 2611459-57-3

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规格 价格 是否有货 数量
1 mg ￥4550
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EphA2 agonist 1 相关抗体

Top Publications Citing Use of Products

查看 Ephrin Receptor 亚型特异性产品:

查看所有亚型
EphA2 EphA3 EphA4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EphA2 agonist 1 (Compound 7bg) is a potent EphA2 receptor agonist. EphA2 agonist 1 shows great potency and selectivity toward EphA2 overexpressed glioblastoma cells and stimulates EphA2 phosphorylation[1].

IC50 & Target

EphA2[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
U-251 IC50
1.9 μM
Compound: 7bg
Antiproliferative activity against human U251 cells overexpressing EPHA2 assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human U251 cells overexpressing EPHA2 assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 32828423]
U-251 IC50
7.91 μM
Compound: 7bg
Antiproliferative activity against wild-type human U251 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against wild-type human U251 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 32828423]
体外研究
(In Vitro)

EphA2 agonist 1 (Compound 7bg) inhibits cell proliferation with IC50 values of 1.90 ± 0.55 μM and 7.91 ± 2.28 μM against U251 EphA2 overexpressed and U251 wild type cells, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

EphA2 agonist 1 相关抗体:
分子量

1019.07

Formula

C50H58N12O12
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : ≥ 50 mg/mL (49.06 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.9813 mL 4.9064 mL 9.8129 mL
5 mM 0.1963 mL 0.9813 mL 1.9626 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

EphA2 agonist 1 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9813 mL 4.9064 mL 9.8129 mL 24.5322 mL
5 mM 0.1963 mL 0.9813 mL 1.9626 mL 4.9064 mL
10 mM 0.0981 mL 0.4906 mL 0.9813 mL 2.4532 mL
15 mM 0.0654 mL 0.3271 mL 0.6542 mL 1.6355 mL
20 mM 0.0491 mL 0.2453 mL 0.4906 mL 1.2266 mL
25 mM 0.0393 mL 0.1963 mL 0.3925 mL 0.9813 mL
30 mM 0.0327 mL 0.1635 mL 0.3271 mL 0.8177 mL
40 mM 0.0245 mL 0.1227 mL 0.2453 mL 0.6133 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EphA2 agonist 12611459-57-3Ephrin ReceptorglioblastomaU251Inhibitorinhibitorinhibit

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产品名称：
EphA2 agonist 1
目录号：
HY-147637
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