2. Apoptosis
  3. TNF Receptor
  4. Epobis

Epobis 是树突状肽，是一种重组形式的促红细胞生成素。Epobis 是一种有效的促红细胞生成素受体 (erythropoietin receptor) 激动剂。Epobis 促进初级运动神经元的神经纤维生成。Epobis 减少 TNF 的释放，并通过血脑屏障。Epobis 有抗炎和增强记忆力的特性。

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Custom Peptide Synthesis

Epobis Chemical Structure

Epobis Chemical Structure

CAS No. : 915091-83-7

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥500
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5 mg ￥1200
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10 mg ￥1800
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100 mg   询价  

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Customer Review

Epobis 相关抗体

Top Publications Citing Use of Products

查看 TNF Receptor 亚型特异性产品:

查看所有亚型
TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Epobis, a dendrimeric peptide, is a recombinant form of erythropoietin. Epobis is a potent erythropoietin receptor agonist. Epobis promotes neuritogenesis in primary motoneurons. Epobis decrease TNF release and crosses the blood-brain barrier. Epobis has anti-inflammatory and memory enhancing properties[1].

体外研究
(In Vitro)

Epobis (0-8.82 μM) stimulates neurite outgrowth from motor neurons in a dose-dependent manner with maximal stimulation at 0.33 μM[1].
Epobis (0-8.82 μM; 24 h) reduces release of TNF and improves the survival of the L929 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Epobis 相关抗体:

Cell Viability Assay[1]

Cell Line: L929 cells
Concentration: 0-8.82 μM
Incubation Time: 24 hours
Result: Had a significantly higher viability of 64% in a concentration of 8.4 μM, whereas the highest viability (68%) in a concentration of 2.7 μM.
体内研究
(In Vivo)

Epobis (10 mg/kg; i.h.; Wistar rats) can cross the blood-brain barrier (BBB)[1].
Epobis (10 mg/kg; i.h.) has an anti-inflammatory effect in mice of multiple sclerosis model[1].
Epobis (10 mg/kg; i.h.; old (>18 month) rats and in rats experiencing early stage AD) improves social memory[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats (200 g)[1]
Dosage: 10 mg/kg
Administration: Subcutaneous injection; once
Result: Had detectable already 15 min after administration and remained detectable in the blood for at least 24 h.
Animal Model: Wistar rats with multiple sclerosis model (200 g)[1]
Dosage: 10 mg/kg
Administration: Subcutaneous injection; once
Result: Had no significant effects on the weight changes or the survival of experimental autoimmune encephalomyelitis (EAE) animals.
Animal Model: Old (>18 month) rats and in rats experiencing early stage AD[1]
Dosage: 10 mg/kg
Administration: Subcutaneous injection; once
Result: Had significantly lower than that of vehicle-treated animals.
分子量

2195.44

Formula

C100H151N27O29
CAS 号
性状

固体

颜色

White to off-white

Sequence Shortening

NENITVPDTKVNFYAWKR
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

H2O 中的溶解度 : ≥ 50 mg/mL (22.77 mM)

DMSO 中的溶解度 : 4 mg/mL (1.82 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.4555 mL 2.2774 mL 4.5549 mL
5 mM 0.0911 mL 0.4555 mL 0.9110 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

Epobis 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 0.4555 mL 2.2774 mL 4.5549 mL 11.3872 mL
H2O 5 mM 0.0911 mL 0.4555 mL 0.9110 mL 2.2774 mL
10 mM 0.0455 mL 0.2277 mL 0.4555 mL 1.1387 mL
15 mM 0.0304 mL 0.1518 mL 0.3037 mL 0.7591 mL
20 mM 0.0228 mL 0.1139 mL 0.2277 mL 0.5694 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Epobis915091-83-7TNF ReceptorTumor Necrosis Factor ReceptorTNFRdendrimeric peptideerythropoietinneuritogenesisanti-inflammatoryblood-brain barriermemory enhancingInhibitorinhibitorinhibit

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