2. Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease Anti-infection
  3. Estrogen Receptor/ERR Endogenous Metabolite Bacterial
  4. Estradiol hemihydrate

Estradiol hemihydrate  (Synonyms: β-Estradiol hemihydrate; 17β-Estradiol hemihydrate; 17β-Oestradiol hemihydrate)

目录号: HY-B0141C
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摩尔计算器

Estradiol (β-Estradiol) hemihydrate 是一种类固醇激素和主要的女性性激素。Estradiol (β-Estradiol) hemihydrate 可上调人子宫内膜干细胞 (hEnSCs) 神经标志物的表达并促进其神经分化。Estradiol (β-Estradiol) hemihydrate 可用于癌症、神经退行性疾病和神经组织工程的相关研究。

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Estradiol hemihydrate Chemical Structure

Estradiol hemihydrate Chemical Structure

CAS No. : 35380-71-3

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Estradiol hemihydrate 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Estradiol (β-Estradiol) hemihydrate is a steroid hormone and the major female sex hormone. Estradiol (β-Estradiol) hemihydrate can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol (β-Estradiol) hemihydrate can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering[1][2].

体外研究
(In Vitro)

Estradiol hemihydrate (10 nM, 7 days) induces neural differentiation and increased neurite branching of human endometrial stem cells (hEnSCs)[1].
Estradiol hemihydrate (17β-estradiol, 10 nM, 7 days) increases the expression of neuron-like cell markers (Tuj-1, nestin and NF-H) in neural-like cells differentiated from hEnSCs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Estradiol hemihydrate 相关抗体:

Cell Differentiation Assay[1]

Cell Line: Isolated human endometrial stem cells (hEnSCs) from human endometrial tissue
Concentration: 10 nM
Incubation Time: 7 days
Result: Increased the percentage of neural marker (Tuj-1, nestin and NF-H)-positive cells of 62.2±1.3%, 71.5±4% and 51.2±1.5% respectively.

Immunofluorescence[1]

Cell Line: Isolated human endometrial stem cells (hEnSCs) from human endometrial tissue
Concentration: 10 nM
Incubation Time: 7 days
Result: Increased the percentage of neural marker (Tuj-1, nestin and NF-H)-positive cells of 62.2±1.3%, 71.5±4% and 51.2±1.5% respectively.
体内研究
(In Vivo)

Estradiol hemihydrate (1 nM, the hippocampal slices from FBN-ARO-KO mice) rescues long-term potentiation (LTP) amplitude[1].
Estradiol hemihydrate (0.0167 mg, implanted s.c., FBN-ARO-KO mice) rescues the molecular and functional deficits in FBN-ARO-KO mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: FBN-ARO-KO Mice[2]
Dosage: 1 nM
Administration: Treated for the hippocampal slices
Result: Rescued long-term potentiation (LTP) amplitude of both male and female mice.
Animal Model: FBN-ARO-KO Mice[2]
Dosage: 0.0167 mg
Administration: Alzet minipumps with Estradiol (implanted s.c.), examined 7 days after minipump implantation.
Result: Restored hippocampal and cortical E2 levels to 93%, phosphorylation of AKT, ERK and CREB in the hippocampus and cortex to 90-95%, BDNF level to 80-90%, restored both synaptophysin and PSD95 in the forebrain.
Rescued the spatial learning and memory defects.
Clinical Trial
分子量

281.39

Formula

C18H26O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Estradiol hemihydrate 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Estradiol hemihydrate35380-71-3β-Estradiol hemihydrate17β-Estradiol hemihydrate17β-Oestradiol hemihydrateEstrogen Receptor/ERREndogenous MetaboliteBacterialEstrogenneural differentiationhuman endometrial stem cellsFBN-ARO-KO modelsteroid sex hormoneuterine fibroidsInhibitorinhibitorinhibit

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