(E/Z)-Farnesyl pyrophosphate  (Synonyms: (E/Z)-Farnesyl diphosphate)

(E/Z)-Farnesyl pyrophosphate ((E/Z)-Farnesyl diphosphate), a 15-carbon isoprenoid, is a metabolic intermediate of the mevalonate (MVA) pathway. (E/Z)-Farnesyl pyrophosphate is a TRPM2 (TRP Channel) agonist, activates TRPM2 opening for ion influx. (E/Z)-Farnesyl pyrophosphate is a key branch substrate for cholesterol synthesis, ubiquinones synthesis, protein farnesylation decoration, and geranyl-geranyl pyrophosphate (GGPP) synthesis^[1].

(E/Z)-Farnesyl pyrophosphate 作为一种确定的危险信号，可触发急性细胞死亡，导致中风中的神经元丢失。(E/Z)-Farnesyl pyrophosphate 含有疏水性 15 碳异戊二烯基链和带大量电荷的焦磷酸头部，导致急性细胞死亡，与其下游代谢途径无关。从机制上讲，细胞外钙流入和阳离子通道瞬时受体电位 melastatin 2 (TRPM2) 在 (E/Z)-Farnesyl pyrophosphate 诱导的细胞死亡中发挥重要作用。(E/Z)-Farnesyl pyrophosphate 酸激活 TRPM2 开放离子流入^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

就大脑中动脉闭塞（MCAO）构建的小鼠模型而言，(E/Z)-Farnesyl pyrophosphate 在脑内蓄积，表明 (E/Z)-Farnesyl pyrophosphate 和TRPM2 危险信号轴在缺血性损伤中的作用。(E/Z)-Farnesyl pyrophosphate/TRPM2 信号轴和 MVA 通路在脑缺血和潜在的神经退行性疾病中发挥重要作用^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

382.33

C₁₅H₂₈O₇P₂

13058-04-3

法尼基焦磷酸

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Jing Chen, et al. Farnesyl pyrophosphate is a new danger signal inducing acute cell death. PLoS Biol. 2021 Apr 26;19(4):e3001134.  [Content Brief]