2. GPCR/G Protein
  3. Bradykinin Receptor
  4. Fasitibant free base

Fasitibant (free base) 是一种强效、选择性、高亲和力、长效的非肽性缓激肽 B2 受体 (BK2 receptor) 拮抗剂。Fasitibant (free base) 具有促炎作用，可用于骨关节炎和类风湿关节炎的研究。

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Fasitibant free base Chemical Structure

Fasitibant free base Chemical Structure

CAS No. : 869939-83-3

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Other Forms of Fasitibant free base:

Fasitibant free base 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 Bradykinin Receptor 亚型特异性产品:

查看所有亚型
Bradykinin B1 Receptor (B1R) Bradykinin B2 Receptor (B2R)

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Fasitibant (free base) is a potent, selective, high affinity, and long-lasting nonpeptide bradykinin B2 (BK2) receptor antagonist. Fasitibant (free base) has proinflammatory effects and can be used for the research of osteoarthritis and rheumatoid arthritis[1].

IC50 & Target[1]

Bradykinin B2 Receptor (B2R)

 

体外研究
(In Vitro)

Fasitibant (free base) (1 µM；30 min) 减少了滑膜细胞中 BK 诱导的 PGE2 形成和 COX-2 基因表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Fasitibant free base 相关抗体:
体内研究
(In Vivo)

Fasitibant (free base) (100 µg；膝盖注射；单剂量) 显著降低了大鼠中卡拉胶 (Carrageenan，HY-125474) 诱导的 IL-1b、IL-6、GRO/CINC-1 滑膜细胞因子的释放，PGE 代谢产物的形成，髓过氧化物酶 (MPO) 的活性，当与地塞米松 (Dexamethasone，HY-14648) 联用时效果更显著[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

764.78

Formula

C36H49Cl2N6O6S+
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Fasitibant free base 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fasitibant869939-83-3Bradykinin ReceptorSynovial fibroblastOsteoarthritisRheumatoid arthritisIL-6Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-106277
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