2. Immunology/Inflammation
  3. FLAP
  4. FEN1-IN-7

FEN1-IN-7 (compound 16) 是一种选择性 Flap 内切酶 1 (FEN1，IC50=18 nM) 抑制剂，参与哺乳动物细胞的 DNA 损伤修复。FEN1-IN-7 还靶向相关的内切酶，着色性干皮病 G 蛋白 (XPG)，IC50 为 3.04 μM。FEN1-IN-7 增加癌细胞对强效 DNA 烷基化剂或甲基化试剂的细胞敏感性。

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FEN1-IN-7 Chemical Structure

FEN1-IN-7 Chemical Structure

CAS No. : 824983-90-6

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FEN1-IN-7 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FEN1-IN-7 (compound 16) is a selective inhibitor of Flap endonuclease-1 (FEN1, IC50=18 nM), involving in mammalian cells to repair DNA damage. FEN1-IN-7 also targets to related endonuclease, xeroderma pigmentosum G (XPG) with an IC50 value of 3.04 μM. FEN1-IN-7 increases the cellular sensitivity of cancer cells to potent DNA alkylating agents or methylating agents[1].

分子量

362.36

Formula

C16H14N2O6S
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

纯度 & 产品资料
参考文献

FEN1-IN-7 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FEN1-IN-7824983-90-6FLAP5-lipoxygenase-activating protein5-LO activating proteinInhibitorinhibitorinhibit

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产品名称：
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目录号：
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