2. Metabolic Enzyme/Protease
  3. Phospholipase
  4. FIPI hydrochloride

FIPI hydrochloride  (Synonyms: 5-Fluoro-2-indolyl deschlorohalopemide hydrochloride)

目录号: HY-12807A
产品使用指南

摩尔计算器

FIPI hydrochloride 是一种磷脂酶 D (PLD) 抑制剂，对 PLD1 和 PLD2 的 IC50 约为 25 nM。FIPI hydrochloride 可调节细胞骨架重组、细胞扩散和趋化性等过程。FIPI hydrochloride 可用于肿瘤的研究。此外，FIPI hydrochloride 能够增强血小板致密颗粒的分泌和聚集，抑制血栓形成、减小缺血性中风梗死体积和改善神经功能。

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FIPI hydrochloride Chemical Structure

FIPI hydrochloride Chemical Structure

CAS No. : 1781834-93-2

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FIPI hydrochloride 的其他形式现货产品:

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FIPI hydrochloride 相关抗体

Top Publications Citing Use of Products

    FIPI hydrochloride purchased from MCE. Usage Cited in: Anal Chem. 2018 Jun 5;90(11):6742-6748.  [Abstract]

    Typical CSLM images of MDA-MB-231 cells incubated with 50 μg/mL RhB-PL-Ti3C2 for 4 h at 37°C in the absence (I) and presence of 1.0 mg/mL FIPI (II), and CSLM images of MCF-7 cells (III) incubated with 50 μg/mL RhB-PL-Ti3C2 for 4 h at 37°C.

    FIPI hydrochloride purchased from MCE. Usage Cited in: J Cell Sci. 2018 Mar 16;131(6). pii: jcs207217.  [Abstract]

    ER:Ras IMR90 cells are treated with solvent or FIPI (250 nM, 2h).Western blotting are performed.

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    Phospholipase A PLD Phospholipase C

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    FIPI hydrochloride is a phospholipase D (PLD) inhibitor with an IC50 for PLD1 and PLD2 of about 25 nM. FIPI hydrochloride regulates cytoskeletal recombination, cell diffusion and chemotaxis. FIPI hydrochloride can be used in cancer research. In addition, FIPI hydrochloride can enhance the secretion and aggregation of platelet dense particles, inhibit thrombosis, reduce ischemic stroke infarct volume and improve nerve function[1][2][3].

    IC50 & Target[1]

    PLD1

     

    PLD2

     

    分子量

    457.93

    Formula

    C23H25ClFN5O2
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    FIPI hydrochloride 相关分类

    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量   浓度   体积   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    FIPI1781834-93-25-Fluoro-2-indolyl deschlorohalopemidePhospholipasePLD1PLD2PLD regulationF-actin cytoskeleton reorganizationcell spreadingchemotaxisautoimmunityInhibitorinhibitorinhibit

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