2. Metabolic Enzyme/Protease Autophagy
  3. Autophagy Phospholipase
  4. FIPI hydrochloride

FIPI hydrochloride  (Synonyms: 5-Fluoro-2-indolyl deschlorohalopemide hydrochloride)

目录号: HY-12807A
产品使用指南

摩尔计算器

FIPI (5-Fluoro-2-indolyl des-chlorohalopemide) hydrochloride 是一种 Halopemide (HY-119093) 的衍生物，是磷脂酶 D (PLD) 抑制剂，对 PLD1 和 PLD2 的 IC50 约为 25 nM 和 20 nM。FIPI hydrochloride 抑制 PLD 对 F-肌动蛋白细胞骨架重组、细胞扩散和趋化性的调节。FIPI hydrochloride 具有用于自身免疫和癌症转移研究的潜力。

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FIPI hydrochloride Chemical Structure

FIPI hydrochloride Chemical Structure

CAS No. : 1781834-93-2

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FIPI hydrochloride 的其他形式现货产品:

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FIPI hydrochloride 相关抗体

Top Publications Citing Use of Products

    FIPI hydrochloride purchased from MCE. Usage Cited in: Anal Chem. 2018 Jun 5;90(11):6742-6748.  [Abstract]

    Typical CSLM images of MDA-MB-231 cells incubated with 50 μg/mL RhB-PL-Ti3C2 for 4 h at 37°C in the absence (I) and presence of 1.0 mg/mL FIPI (II), and CSLM images of MCF-7 cells (III) incubated with 50 μg/mL RhB-PL-Ti3C2 for 4 h at 37°C.

    FIPI hydrochloride purchased from MCE. Usage Cited in: J Cell Sci. 2018 Mar 16;131(6). pii: jcs207217.  [Abstract]

    ER:Ras IMR90 cells are treated with solvent or FIPI (250 nM, 2h).Western blotting are performed.

    查看 Phospholipase 亚型特异性产品:

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    Phospholipase A PLD Phospholipase C

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    FIPI (5-Fluoro-2-indolyl des-chlorohalopemide) hydrochloride, a derivative of Halopemide (HY-119093), is a phospholipase D (PLD) inhibitor with IC50s of approximately 25 nM and 20 nM for PLD1 and PLD2, respectively. FIPI hydrochloride inhibits PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis. FIPI hydrochloride has the potential for autoimmunity and cancer metastasis research[1][2][3].

    IC50 & Target

    IC50: 25 nM (PLD1), 20 nM (PLD2)
    分子量

    457.93

    Formula

    C23H25ClFN5O2
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    FIPI hydrochloride 相关分类

    • 摩尔计算器

    • 稀释计算器

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    The dilution calculator equation

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    FIPI1781834-93-25-Fluoro-2-indolyl deschlorohalopemideAutophagyPhospholipasePLD1PLD2PLD regulationF-actin cytoskeleton reorganizationcell spreadingchemotaxisautoimmunityInhibitorinhibitorinhibit

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