2. Others Metabolic Enzyme/Protease Immunology/Inflammation NF-κB Apoptosis
  3. Fluorescent Dye Reactive Oxygen Species TNF Receptor Interleukin Related SOD
  4. Fluorene

Fluorene  (Synonyms: 芴)

目录号: HY-W026772 纯度: 98.00%
COA 产品使用指南 技术支持

Fluorene 是一种具有口服活性的多环芳烃 (PAH)，是其他芴类化合物的前体。Fluorene 及其衍生物可作为芴的染料前体。Fluorene 可在 A549 细胞中通过增加 ROS 和 SOD 生成、加剧脂质过氧化、调节抗氧化酶活性变化以及上调促炎因子 TNF-α 和 IL-6 的表达，来诱导氧化应激和炎症反应。在体内，Fluorene 表现出抗焦虑活性。Fluorene 有望用于炎症和神经疾病的研究。

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Fluorene Chemical Structure

Fluorene Chemical Structure

CAS No. : 86-73-7

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10 mM * 1 mL in DMSO ￥110
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500 mg ￥100
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1 g ￥150
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Other Forms of Fluorene:

Fluorene 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

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TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Fluorene is an orally active polycyclic aromatic hydrocarbon (PAH) and a precursor to other fluorene-based compounds. Fluorene and its derivatives serve as dye precursors for fluorene synthesis. In A549 cells, Fluorene induces oxidative stress and inflammatory responses by increasing ROS and SOD generation, exacerbating lipid peroxidation, modulating antioxidant enzyme activity, and upregulating the expression of pro-inflammatory factors TNF-α and IL-6. In vivo, Fluorene exhibits anxiolytic activity. Fluorene holds potential for research in inflammation and neurological disorders[1][2][3].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MDA-MB-231 IC50
> 50 μM
Compound: Fluorene
Cytotoxicity against triple-negative human MDA-MB-231 cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay
Cytotoxicity against triple-negative human MDA-MB-231 cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay
[PMID: 32726747]
体外研究
(In Vitro)

Fluorene (200-800 μM，24-48 小时) 在 A549 细胞中诱导氧化应激和炎症反应，表现为 ROS 生成增加、脂质过氧化加剧、抗氧化酶活性变化以及促炎因子 TNF-α 和 IL-6 表达上调[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Fluorene 相关抗体:

Western Blot Analysis[1]

Cell Line: A549 human lung epithelial cells (lung injury)
Concentration: 200, 400, 600, 800 μM
Incubation Time: 24 hours, 48 hours
Result: Upregulated TNF-α and IL-6 mRNA and protein expression levels. Additionally, SP-A expression increased in Fluorene-treated groups (400 and 600 μM) but decreased in the PAH mixture-treated group (600 μM).

Cell Viability Assay[1]

Cell Line: A549 human lung epithelial cells (lung injury)
Concentration: 200, 400, 600, 800 μM
Incubation Time: 24 hours, 48 hours
Result: Induced ROS generation in A549 cells, increased MDA content, and enhanced SOD and CAT activity.
体内研究
(In Vivo)

Fluorene (100 mg/kg，口服或腹腔注射，每日一次，持续 60 天) 会抑制 Wistar 大鼠体重增长并增加其肝脏相对重量，其中腹腔注射途径导致血液和大脑中 Fluorene 及其代谢物水平更高[3]。
Fluorene (1, 10 mg/kg/day, 口服或腹腔注射，每日一次，持续 60 天) 会降低 Wistar 大鼠焦虑水平，但未影响运动能力或学习能力[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Fluorene oral or intraperitoneal (i.p.) administration-induced body weight and organ changes in Wistar rats[1]
Dosage: 1, 10, 100 mg/kg
Administration: Oral gavage (p.o.) or intraperitoneal injection (i.p.), once daily for 60 days
Result: Exhibited significantly reduced weight gain after 28 days and increased relative liver weight (The 100 mg/kg group). Additionally, higher concentrations of Fluorene and its hydroxylated metabolites were detected in the blood and brain of i.p.-treated rats compared to p.o.-treated ones.
Reduced anxiety levels in rats (1, 10 mg/kg), while the high dose (100 mg/kg) showed no significant changes. No effects on locomotor activity or learning ability were observed.
分子量

166.22

Formula

C13H10
CAS 号
性状

固体

颜色

Off-white to light brown

中文名称

芴
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

RT, protect from light

In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 62.5 mg/mL (376.00 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 6.0160 mL 30.0801 mL 60.1601 mL
5 mM 1.2032 mL 6.0160 mL 12.0320 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用，-20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.35%

COA (292 KB) HNMR (129 KB) RP-HPLC (331 KB)

产品使用指南 (1538 KB)
参考文献

Fluorene 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用，-20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.0160 mL 30.0801 mL 60.1601 mL 150.4004 mL
5 mM 1.2032 mL 6.0160 mL 12.0320 mL 30.0801 mL
10 mM 0.6016 mL 3.0080 mL 6.0160 mL 15.0400 mL
15 mM 0.4011 mL 2.0053 mL 4.0107 mL 10.0267 mL
20 mM 0.3008 mL 1.5040 mL 3.0080 mL 7.5200 mL
25 mM 0.2406 mL 1.2032 mL 2.4064 mL 6.0160 mL
30 mM 0.2005 mL 1.0027 mL 2.0053 mL 5.0133 mL
40 mM 0.1504 mL 0.7520 mL 1.5040 mL 3.7600 mL
50 mM 0.1203 mL 0.6016 mL 1.2032 mL 3.0080 mL
60 mM 0.1003 mL 0.5013 mL 1.0027 mL 2.5067 mL
80 mM 0.0752 mL 0.3760 mL 0.7520 mL 1.8800 mL
100 mM 0.0602 mL 0.3008 mL 0.6016 mL 1.5040 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fluorene86-73-7芴Fluorescent DyeReactive Oxygen SpeciesTNF ReceptorInterleukin RelatedSODTumor Necrosis Factor ReceptorTNFRILSuperoxide DismutasePAHdyeprecursorpolycyclic aromatic hydrocarbonWistar ratsA549 human lung epithelial cells (lung injury)ROSTNF-αoxidative stressInhibitorinhibitorinhibit

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