2. GPCR/G Protein Neuronal Signaling
  3. mGluR CaMK Tau Protein
  4. FO-4-15

FO-4-15 是一种 mGluR1/CaMKIIα 激活剂。FO-4-15 在人神经母细胞瘤 (SH-SY5Y) 细胞中具有抗 H2O2 保护作用。FO-4-15 可以在阿尔兹海默症小鼠中通过激活 mGluR1/CaMKIIα 通路来改善认知障碍，并可以减少 Aβ 积累、Tau 高磷酸化和突触损伤。

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FO-4-15 Chemical Structure

FO-4-15 Chemical Structure

CAS No. : 1030759-58-0

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FO-4-15 相关抗体

Top Publications Citing Use of Products

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mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

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CaMK III CaMK II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FO-4-15 is an mGluR1/CaMKIIα activator. FO-4-15 has a protective effect against H2O2 in human neuroblastoma (SH-SY5Y) cells. FO-4-15 can improve cognitive impairment in Alzheimer’s disease mice by activating the mGluR1/CaMKIIα pathway, and can reduce Aβ accumulation, hyperphosphorylated Tau, and synaptic damage[1].
分子量

388.44

Formula

C18H20N4O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FO-4-15 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FO-4-151030759-58-0mGluRCaMKTau ProteinMetabotropic glutamate receptorsCalmodulin-dependent protein kinasesCalmodulin-dependent kinasesmGluR1/CaMKIIαSH-SY5YAβTau cognitive impairmentInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-162860
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