2. Immunology/Inflammation Metabolic Enzyme/Protease Anti-infection
  3. Toll-like Receptor (TLR) MMP HSV Antibiotic
  4. FSL-1 TFA

FSL-1 TFA 是细菌衍生的一种 Toll 样受体 2/6 (TLR2/6) 激动剂，可增强对 HSV-2 感染的抵抗力。FSL-1 TFA 通过 TLR2 和 NF-κB/AP-1 信号通路诱导 MMP-9 产生。

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Custom Peptide Synthesis

FSL-1 TFA Chemical Structure

FSL-1 TFA Chemical Structure

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规格 价格 是否有货 数量
100 μg ￥1600
In-stock

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Customer Review

Other Forms of FSL-1 TFA:

FSL-1 TFA 相关抗体

Top Publications Citing Use of Products

查看 Toll-like Receptor (TLR) 亚型特异性产品:

查看所有亚型
TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

查看 MMP 亚型特异性产品:

查看所有亚型
MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

查看 HSV 亚型特异性产品:

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HSV-1 HSV-2 HSV

查看 Antibiotic 亚型特异性产品:

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FSL-1 TFA, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection[1]. FSL-1 TFA induces MMP-9 production through TLR2 and NF-κB/AP-1 signaling pathways in monocytic THP-1 cells[2].

IC50 & Target[1][2]

TLR2

 

HSV-2

 

TLR6

 

MMP-9

 

体外研究
(In Vitro)

FSL-1 TFA 显著降低人类阴道上皮细胞 (EC) 中的 HSV-2 复制[1]。
FSL-1 TFA 通过详细阐述对实验性生殖器 HSV-2 感染的显著抵抗力细胞因子反应谱[1]。
FSL-1 TFA (50 ng/mL，24 小时) 在人单核细胞 THP-1 细胞的 mRNA 和蛋白质水平上诱导 MMP-9 表达[2]。
FSL-1 TFA 激活 MAP 激酶/NF-κB 信号通路[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

FSL-1 TFA 相关抗体:

Cell Viability Assay[1]

Cell Line: V11I, V12I or V19I immortalized human vaginal EC
Concentration: 6 μg or 0.1 μg
Incubation Time: Added at 24, 6 or just prior to HSV-2 inoculation (104pfu/well)
Result: The 6 μg does produced significant reductions when delivered at 24 or 6 h prior to HSV-2 inoculation. The 0.1 μg dose produced reduced HSV-2 replication at 24 or 6 h prior to viral challenge.
体内研究
(In Vivo)

FSL-1 TFA 显著保护小鼠免受生殖器 HSV-2 攻击[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Swiss-Webster mice (weighing 20-25 g)[1]
Dosage: 2 or 6 μg
Administration: Delivered vaginally using a positive displacement pipet, prior to or following viral challenge as specified for each experiment.
Result: The 2 μg does delivered 6 h prior to HSV-2 challenge increased the ID50 (260 pfu) and LD50 (660 pfu) by 10-fold compared to DPBS vehicle control.
The single 6 μg dose produced significantly improved outcomes compared to DPBS vehicle application.
分子量

1666.16 (free acid)

Formula

C84H140N14O18S.xC2HF3O2
性状

固体

颜色

White to off-white

Sequence Shortening

S-(2, 3-Bispalmitoyloxypropyl)-CGDPKHPKSF
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 50 mg/mL (超声助溶)

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

FSL-1 TFA 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FSL-1FSL1FSL 1Toll-like Receptor (TLR)MMPHSVAntibioticMatrix metalloproteinasesHerpes simplex virusInhibitorinhibitorinhibit

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目录号：
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