2. Anti-infection
  3. HIV
  4. GCA-186

GCA-186 是一种有效的抗 HIV-1 试剂。GCA-186 对野生型和突变型 HIV-1 株均具有高度活性，抑制 IIIB、III B-R(Y181C)、NL4-3 和 NL4-3K103N，EC50 分别为 1、180、1 和 40 nM。

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GCA-186 Chemical Structure

GCA-186 Chemical Structure

CAS No. : 149950-61-8

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3.  试用装只面向终端客户。

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GCA-186 相关抗体

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查看 HIV 亚型特异性产品:

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HIV HIV-1 HIV-2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GCA-186 is a potent anti-HIV-1 agent. GCA-186 is highly active against both wild type and mutated HIV-1 strains with EC50s of 1, 180, 1, and 40 nM for IIIB, IIIB-R(Y181C), NL4-3 and NL4-3K103N of HIV-1 strains, respectively[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MT4 IC50
0.001 μM
Compound: GCA-186
Anti-HIV-1 activity against LAI strain in MT-4 cells by the MTT method
Anti-HIV-1 activity against LAI strain in MT-4 cells by the MTT method
[PMID: 14643315]
MT4 IC50
0.04 μM
Compound: GCA-186
Anti-HIV-1 activity against K103N strain in MT-4 cells by the MTT method
Anti-HIV-1 activity against K103N strain in MT-4 cells by the MTT method
[PMID: 14643315]
MT4 IC50
0.18 μM
Compound: GCA-186
Anti-HIV-1 activity against Y181C strain, in MT-4 cells by the MTT method
Anti-HIV-1 activity against Y181C strain, in MT-4 cells by the MTT method
[PMID: 14643315]
MT4 CC50
43 μM
Compound: 34
Cytotoxic concentration required to reduce the viability of mock-infected MT-4 cells by 50%
Cytotoxic concentration required to reduce the viability of mock-infected MT-4 cells by 50%
[PMID: 7636846]
体外研究
(In Vitro)

GCA-186 shows antiviral activity (EC50=0.6 nM) and cytotoxicity against HIV-1 in MT-4 cells (CC50=43 μM)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GCA-186 相关抗体:
分子量

330.42

Formula

C19H26N2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GCA-186 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GCA-186149950-61-8GCA186GCA 186HIVHuman immunodeficiency viruswild typemutant strainscytotoxicityantiviralInhibitorinhibitorinhibit

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产品名称：
GCA-186
目录号：
HY-116528
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