2. GPCR/G Protein
  3. Mas-related G-protein-coupled Receptor (MRGPR)
  4. GE1111

GE1111 是 mas 相关 G 蛋白偶联受体 X2 (MRGPRX2) 的拮抗剂，IC50 为 9.42 μM。GE1111 抑制肥大细胞脱颗粒，IC50 为 4.7 μM。GE1111 在 C48/80 (HY-130592) 诱发的全身过敏反应模型中表现出抗过敏​​和抗炎作用。

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GE1111 Chemical Structure

GE1111 Chemical Structure

CAS No. : 2883669-12-1

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GE1111 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GE1111 is the antagonist for mas-related G protein-coupled receptor X2 (MRGPRX2) with an IC50 of 9.42 μM. GE1111 inhibits mast cell degranulation with an IC50 of 4.7 μM. GE1111 exhibits anti-allergic and anti-inflammatory effects in C48/80 (HY-130592)-induced systemic allergic reaction model[1].

IC50 & Target

IC50: 9.42 μM (MRGPRX2)
分子量

466.48

Formula

C28H22N2O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GE1111 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GE11112883669-12-1GE 1111GE-1111Mas-related G-protein-coupled Receptor (MRGPR)HTLALAD-2anti-allergicInhibitorinhibitorinhibit

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