PIGK - phosphatidylinositol glycan anchor biosynthesis class K Gene

中文名称：磷脂酰肌醇聚糖锚生物合成 K 类

种属: Homo sapiens

同用名: GPI8; NEDHCAS

基因 ID: 10026 | 基因类型: protein coding

关于 PIGK

Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:77,088,989-77,219,430 (from NCBI)

This gene has 5 transcripts (splice variants), 212 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in thyroid (RPKM 12.4), adrenal (RPKM 9.0) and 25 other tissues.

功能概要

该基因编码参与糖基磷脂酰肌醇 (GPI) -锚生物合成的半胱氨酸蛋白酶家族 C13 的成员。 GPI 锚是一种在许多血细胞上发现的糖脂，用于将蛋白质锚定到细胞表面。该蛋白质是多亚基酶 GPI 转酰胺酶的成员，被认为是其酶促成分。 GPI 转酰胺酶通过催化完全组装的 GPI 单位向蛋白质的转移，介导 GPI 在内质网中的锚定。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the cysteine protease family C13 that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is a member of the multisubunit Enzyme, GPI transamidase and is thought to be its enzymatic component. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. [provided by RefSeq, Jul 2008]

PIGK 基因产物(1)

mRNA	Protein	Name
NM_005482.3	NP_005473.1	GPI-anchor transamidase precursor

PIGK 蛋白结构

Peptidase_C13

0
100
200
300
395 a.a.

蛋白主名

其他名称

GPI-anchor transamidase

GPI transamidase subunit

PIGK 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PIGK	Q92643	GPAA1	Homo sapiens	O43292	Anti Tag CoIP	33961781
种属内	PIGK	Q92643	GPAA1	Homo sapiens	O43292	Anti Tag CoIP	10793132
种属内	PIGK	Q92643	GPAA1	Homo sapiens	O43292	Anti Tag CoIP	28514442
种属内	PIGK	Q92643	GPAA1	Homo sapiens	O43292	TAP	12802054
种属内	PIGK	Q92643	GPAA1	Homo sapiens	O43292	Anti Tag CoIP	11483512
种属内	PIGK	Q92643	PIGT	Homo sapiens	Q969N2	Anti Tag CoIP	33961781
种属内	PIGK	Q92643	PIGT	Homo sapiens	Q969N2	Anti Tag CoIP	28514442
种属内	PIGK	Q92643	PIGT	Homo sapiens	Q969N2	TAP	12802054
种属内	PIGK	Q92643	PIGT	Homo sapiens	Q969N2	Anti Tag CoIP	11483512

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Neurodevelopmental Disorder With Or Without Hypotonia, Seizures, And Cerebellar Atrophy

Glycosylphosphatidylinositol Biosynthesis Defect 13	Neurodevelopmental Disorder With Hypotonia And Cerebellar Atrophy, With Or Without Seizures
Gpibd13	NEDHCAS
Glycosylphosphatidylinositol Biosynthesis Defect 22	Gpibd22
NEDHSCA	Intellectual Developmental Disorder, Autosomal Recessive 53, Formerly
Mrt53, Formerly	Mental Retardation, Autosomal Recessive 53, Formerly
Early-Onset Epilepsy-Intellectual Disability-Brain Anomalies Syndrome	Congenital Disorder Of Glycosylation Due To Pigg Deficiency
Pigg-Cdg	Intellectual Developmental Disorder, Autosomal Recessive 53
MRT53

Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome 3

MCAHS3	Glycosylphosphatidylinositol Biosynthesis Defect 7
Gpibd7	Intellectual Disability-Seizures-Hypophosphatasia-Ophthalmic-Skeletal Anomalies Syndrome
Congenital Disorder Of Glycosylation Due To Pigt Deficiency	Mcahs Type 3
Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome Type 3	Pigt-Cdg
Multiple Congenital Anomalies, Hypotonia, Seizures Syndrome, Type 3

Hypotonia

Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome

Pign-Cdg	Congenital Disorder Of Glycosylation Due To Pign Deficiency
Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome 1	Mcahs1

Anterior Segment Dysgenesis 4

Iridogoniodysgenesis Syndrome	Iridogoniodysgenesis, Type 2
Irid2	Iridogoniodysgenesis Type 2
ASGD4	Igds
Iris Hypoplasia With Early-Onset Glaucoma, Autosomal Dominant	Ihga
Irid 1	Irid 2
Iridogoniodysgenesis Type 1	Igds2
Iridogoniodysgenesis Syndrome 2	Iridogoniodysgenesis, Type 1

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Rapp-Hodgkin Syndrome

RHS	Anhidrotic Ectodermal Dysplasia With Cleft Lip/Palate
Ectodermal Dysplasia, Rapp-Hodgkin Type	Rapp-Hodgkin Ectodermal Dysplasia Syndrome
Ectodermal Dysplasia, Anhidrotic, With Cleft Lip/Palate	Ectodermal Dysplasia Syndrome, Rapp-Hodgkin Type
Edrh	Rapp-Hodgkin Ectodermal Dysplasia
Orofacial Cleft 8

Sleeping Sickness

African Trypanosomiasis	African Sleeping Sickness
Trypanosomiasis, Human East-African	Trypanosomiasis, East African
Trypanosomiasis African	Trypanosomiasis, African
Human African Trypanosomiasis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10493	PIGK Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	PIGK	RGD	RGD:1306753
Felis catus	PIGK	VGNC	VGNC:68845
Canis familiaris	PIGK	VGNC	VGNC:44535
Macaca mulatta	PIGK	VGNC	VGNC:75988
Mus musculus	PIGK	MGD	MGI:1913863
Bos taurus	PIGK	VGNC	VGNC:32870

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PIGK - phosphatidylinositol glycan anchor biosynthesis class K Gene

关于 PIGK

功能概要

PIGK 基因产物(1)

PIGK 蛋白结构

PIGK 蛋白互作信息

关联疾病

直系同源

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PIGK - phosphatidylinositol glycan anchor biosynthesis class K Gene

关于 PIGK

功能概要

PIGK 基因产物(1)

PIGK 蛋白结构

PIGK 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z