1. Gene
  2. SCAMP2 - secretory carrier membrane protein 2 Gene

SCAMP2 - secretory carrier membrane protein 2 Gene

中文名称:分泌性载体膜蛋白 2

种属: Homo sapiens

基因 ID: 10066 | 基因类型: protein coding

关于 SCAMP2

Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:74,843,730-74,873,365 (from NCBI)

This gene has 12 transcripts (splice variants), 272 orthologues and 4 paralogues. Ubiquitous expression in colon (RPKM 41.0), small intestine (RPKM 37.7) and 25 other tissues.

功能概要

该基因产物属于 SCAMP 蛋白家族,是分泌性载体膜蛋白。它们在后高尔基体循环途径中充当细胞表面的载体。不同的家族成员是不同基因高度相关的产物,通常一起表达。这些发现表明,SCAMP 可能在囊泡运输过程中的同一位点发挥作用,而不是在不同的途径中发挥作用。交替剪接导致多个转录本变体。[RefSeq 提供,2016 年 3 月]

This gene product belongs to the SCAMP family of proteins which are secretory carrier membrane proteins. They function as carriers to the cell surface in post-golgi recycling pathways. Different family members are highly related products of distinct genes, and are usually expressed together. These findings suggest that the SCAMPs may function at the same site during vesicular transport rather than in separate pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

SCAMP2 基因产物(2)

mRNA Protein Name
NM_001320778.2 NP_001307707.1 secretory carrier-associated membrane protein 2 isoform 1
NM_005697.5 NP_005688.2 secretory carrier-associated membrane protein 2 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15840657 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein transport IDA
IDA: 通过直接分析推断
15840657 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in membrane IDA
IDA: 通过直接分析推断
15840657 GOA
located in recycling endosome membrane IDA
IDA: 通过直接分析推断
15840657 GOA
located in trans-Golgi network membrane IDA
IDA: 通过直接分析推断
15840657 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SCAMP2 蛋白结构

SCAMP

SCAMP: SCAMP family (116 - 294)

  • 0
  • 100
  • 200
  • 300
  • 329 a.a.
蛋白主名 其他名称

secretory carrier-associated membrane protein 2

testis secretory sperm-binding protein Li 219p

SCAMP2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SCAMP2 O15127 SLC41A1 Homo sapiens Q8IVJ1
Validated Y2H
32296183
Intra SCAMP2 O15127 FLNA Homo sapiens P21333-2
Validated Y2H
32814053
Intra SCAMP2 O15127 FLNA Homo sapiens P21333-2
Y2H Pooling
32814053
Intra SCAMP2 O15127 FLNA Homo sapiens P21333-2
Y2H Array
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Chromosome 15q24 Deletion Syndrome

15q24 Microdeletion Syndrome

Del(15)(Q24)

Monosomy 15q24

15q24 Microdeletion

15q24 Deletion

Interstitial Deletion Of Chromosome 15q24

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus SCAMP2 VGNC VGNC:64896
Macaca mulatta SCAMP2 VGNC VGNC:76974
Bos taurus SCAMP2 VGNC VGNC:34316
Rattus norvegicus SCAMP2 RGD RGD:68348
Mus musculus SCAMP2 MGD MGI:1346518
Canis familiaris SCAMP2 VGNC VGNC:45891