2. Gene
  3. TRAP1 - TNF receptor associated protein 1 Gene

TRAP1 - TNF receptor associated protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：TNF 受体相关蛋白 1

种属: Homo sapiens

同用名: HSP75; HSP 75; HSP90L; TRAP-1

基因 ID: 10131 | 基因类型: protein coding

关于 TRAP1

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:3,658,037-3,717,524 (from NCBI)

This gene has 17 transcripts (splice variants), 210 orthologues and 3 paralogues. Ubiquitous expression in kidney (RPKM 31.7), heart (RPKM 25.6) and 25 other tissues.

功能概要

该基因编码的线粒体伴侣蛋白是热休克蛋白 90 (HSP90) 家族的成员。编码的蛋白质具有 ATP 酶活性并与 I 型肿瘤坏死因子相互作用。该蛋白质可能在调节细胞应激反应中发挥作用。交替剪接导致多个转录本变体。[RefSeq 提供，2013 年 1 月]

This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

TRAP1 基因产物(2)

mRNA Protein Name
NM_001272049.2 NP_001258978.1 heat shock protein 75 kDa, mitochondrial isoform 2
NM_016292.3 NP_057376.2 heat shock protein 75 kDa, mitochondrial isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17579517 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
17579517 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of cellular respiration IMP
IMP: 通过突变表型推断
23564345 GOA
involved in translational attenuation IMP
IMP: 通过突变表型推断
24113185 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrial inner membrane IDA
IDA: 通过直接分析推断
23564345 GOA
located in mitochondrial matrix IDA
IDA: 通过直接分析推断
23564345 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
17579517 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TRAP1 蛋白结构

HATPase_c_3

HATPase_c_3: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (110 - 223)

HSP90

HSP90: Hsp90 protein (291 - 701)

  • 0
  • 200
  • 400
  • 600
  • 704 a.a.
蛋白主名 其他名称

heat shock protein 75 kDa, mitochondrial

TNFR-associated protein 1

重组 TRAP1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71537 TRAP1 Protein, Human (GST) Q12931 (60S-308E) ≥95%

TRAP1 抗体

目录号 产品名 应用 反应物种
HY-P82880 Hsp75 Antibody (YA2625) WB, IHC-P, ICC/IF Human

关联疾病

疾病名称 别名
Cakut

Renal Or Urinary Tract Malformation

Congenital Anomalies Of Kidney And Urinary Tract

Congenital Anomaly Of Kidney And Urinary Tract

Congenital Anomalies Of The Kidney And Urinary Tract

Kidney And Urinary Tract, Anomalies, Congenital

Renal Hypodysplasia, Nonsyndromic, 1
Vacterl Association, X-Linked, With Or Without Hydrocephalus

VACTERLX

X-Linked Vacterl Association

Vacterl-H, X-Linked

Vacterl Association, X-Linked

Vacterl Association, X-Linked With Or Without Hydrocephalus

Vacterl Association X-Linked With Or Without Hydrocephalus

Vacterl Syndrome

Vertebral Anal Tracheoesophageal Esophageal Radial Anomalies

X-Linked Vacterl-H

Vacterl Association

Vacterl Association With Hydrocephalus
Retinitis Pigmentosa 71

RP71

Retinitis Pigmentosa, Type 71
Short-Rib Thoracic Dysplasia 10 With Or Without Polydactyly

SRTD10

Short-Rib Thoracic Dysplasia 10 Without Polydactyly

Short Rib-Polydactyly Syndrome
Vacterl Association

Vater Association

Vater Syndrome
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (12)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-W111141 BCN-OH 99.15% 否
HY-10214 SNX-2112 99.45% 否
HY-10942 VER-82576 Inhibitor 98.76% 否
HY-117395 PU-H54 Inhibitor 99.04% 否
HY-115781 DN401 Inhibitor ≥99.0% 否
HY-147696 SMTIN-T140 99.58% 否
HY-155063 TRAP1-IN-1 Inhibitor / 否
HY-144830 6BrCaQ Inhibitor / 否
HY-144831 6BrCaQ-C10-TPP Inhibitor / 否
HY-155064 TRAP1-IN-2 Inhibitor / 否
HY-169369 TRAP-1 / 否
HY-RS14984 TRAP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus TRAP1 VGNC VGNC:36283
Macaca mulatta TRAP1 VGNC VGNC:79019
Mus musculus TRAP1 MGD MGI:1915265
Felis catus TRAP1 VGNC VGNC:66507
Rattus norvegicus TRAP1 RGD RGD:1359733
Canis familiaris TRAP1 VGNC VGNC:47776
Others TRAP1 NCBI
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