2. Gene
  3. LPCAT3 - lysophosphatidylcholine acyltransferase 3 Gene

LPCAT3 - lysophosphatidylcholine acyltransferase 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶血磷脂酰胆碱酰基转移酶 3

种属: Homo sapiens

同用名: C3F; LPCAT; LPSAT; OACT5; nessy; MBOAT5; LPLAT 5; LPLAT12

基因 ID: 10162 | 基因类型: protein coding

关于 LPCAT3

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:6,976,185-7,018,476 (from NCBI)

This gene has 13 transcripts (splice variants), 205 orthologues and 5 paralogues. Ubiquitous expression in duodenum (RPKM 59.9), small intestine (RPKM 50.5) and 25 other tissues.

功能概要

启用 1-酰基甘油磷酸胆碱 O-酰基转移酶活性； 1-酰基甘油磷酸乙醇胺 O-酰基转移酶活性；和 1-酰基甘油磷酸丝氨酸 O-酰基转移酶活性。参与磷脂酰胆碱酰基链重塑；磷脂酰乙醇胺酰基链重构；和磷脂酰丝氨酸酰基链重塑。位于内质网膜上。 [由基因组资源联盟提供，2022 年 4 月]

Enables 1-acylglycerophosphocholine O-acyltransferase activity; 1-acylglycerophosphoethanolamine O-acyltransferase activity; and 1-acylglycerophosphoserine O-acyltransferase activity. Involved in phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; and phosphatidylserine acyl-chain remodeling. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

LPCAT3 基因产物(1)

mRNA Protein Name
NM_005768.6 NP_005759.4 lysophospholipid acyltransferase 5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 1-acylglycerophosphocholine O-acyltransferase activity IDA
IDA: 通过直接分析推断
18195019 GOA
enables 1-acylglycerophosphocholine O-acyltransferase activity IMP
IMP: 通过突变表型推断
22511767 GOA
enables 1-acylglycerophosphoethanolamine O-acyltransferase activity IDA
IDA: 通过直接分析推断
18772128 GOA
enables 1-acylglycerophosphoserine O-acyltransferase activity IDA
IDA: 通过直接分析推断
18195019 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in phosphatidylcholine acyl-chain remodeling IDA
IDA: 通过直接分析推断
18195019 GOA
involved in phosphatidylcholine acyl-chain remodeling IMP
IMP: 通过突变表型推断
18782225 GOA
involved in phosphatidylethanolamine acyl-chain remodeling IDA
IDA: 通过直接分析推断
18772128 GOA
involved in phosphatidylethanolamine acyl-chain remodeling IMP
IMP: 通过突变表型推断
18782225 GOA
involved in phosphatidylserine acyl-chain remodeling IDA
IDA: 通过直接分析推断
18195019 GOA
involved in phosphatidylserine acyl-chain remodeling IMP
IMP: 通过突变表型推断
18782225 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
18195019 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LPCAT3 蛋白结构

MBOAT

MBOAT: MBOAT, membrane-bound O-acyltransferase family (128 - 437)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 487 a.a.
蛋白主名 其他名称

lysophospholipid acyltransferase 5

1-acylglycerophosphocholine O-acyltransferase

关联疾病

疾病名称 别名
Brachydactyly-Syndactyly Syndrome

BDSD

Brachydactyly-Syndactyly-Oligodactyly Syndrome

Brachydactyly-Syndactyly, Zhao Type

BDSDO
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-158790 (R)-HTS-3 Inhibitor 99.29% 否
HY-RS07766 LPCAT3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta LPCAT3 VGNC VGNC:74405
Felis catus LPCAT3 VGNC VGNC:63266
Canis familiaris LPCAT3 VGNC VGNC:54322
Bos taurus LPCAT3 VGNC VGNC:30963
Rattus norvegicus LPCAT3 RGD RGD:1310223
Mus musculus LPCAT3 MGD MGI:1315211
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