WASF2 - WASP family member 2 Gene

中文名称：黄蜂家族成员 2

种属: Homo sapiens

同用名: IMD2; SCAR2; WASF4; WAVE2; dJ393P12.2

关于 WASF2

功能概要

该基因编码 Wiskott-Aldrich 综合征蛋白家族的成员。该基因产物是一种蛋白质，可形成连接受体激酶和肌动蛋白的多蛋白复合物。与肌动蛋白的结合通过所有家族成员的 C 端 verprolin 同源域发生。多蛋白复合物用于传递涉及细胞形状、运动或功能变化的信号。根据最近的基因组序列比较，已更改已发布的地图位置 (PMID：10381382) ，这表明表达的基因位于染色体 1，而假基因可能位于染色体 X。已发现两个编码不同亚型的转录变体对于这个基因。[RefSeq 提供，2011 年 1 月]

This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]