2. Gene
  3. TRIM13 - tripartite motif containing 13 Gene

TRIM13 - tripartite motif containing 13 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含三方基序 13

种属: Homo sapiens

同用名: CAR; LEU5; RFP2; DLEU5; RNF77

基因 ID: 10206 | 基因类型: protein coding

关于 TRIM13

Cytogenetic location: 13q14.2 Genomic coordinates (GRCh38): 13:49,997,042-50,018,467 (from NCBI)

This gene has 8 transcripts (splice variants), 211 orthologues and 80 paralogues. Broad expression in testis (RPKM 17.7), bone marrow (RPKM 8.8) and 25 other tissues.

功能概要

该基因编码三联基序 (TRIM) 家族的成员。 TRIM 基序包括三个锌结合域、一个 RING、一个 B-box 类型 1 和一个 B-box 类型 2，以及一个卷曲螺旋区域。该基因位于 B 细胞慢性淋巴细胞白血病最小缺失区域内的 13 号染色体上。已发现该基因的多个选择性剪接转录物变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This gene is located on chromosome 13 within the minimal deletion region for B-cell chronic lymphocytic leukemia. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

TRIM13 基因产物(4)

mRNA Protein Name
NM_001007278.3 NP_001007279.1 E3 ubiquitin-protein ligase TRIM13 isoform 2
NM_005798.5 NP_005789.2 E3 ubiquitin-protein ligase TRIM13 isoform 1
NM_052811.4 NP_434698.1 E3 ubiquitin-protein ligase TRIM13 isoform 1
NM_213590.3 NP_998755.1 E3 ubiquitin-protein ligase TRIM13 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17314412 GOA
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
23077300 GOA
enables ubiquitin-like protein ligase activity IDA
IDA: 通过直接分析推断
21333377 GOA
enables ubiquitin-protein transferase activity IDA
IDA: 通过直接分析推断
17314412 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ERAD pathway IDA
IDA: 通过直接分析推断
17314412 GOA
involved in innate immune response IDA
IDA: 通过直接分析推断
18248090 GOA
involved in negative regulation of viral transcription IDA
IDA: 通过直接分析推断
18248090 GOA
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: 通过突变表型推断
23077300 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
23077300 GOA
involved in positive regulation of macroautophagy IDA
IDA: 通过直接分析推断
22178386 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
17314412 GOA
involved in protein autoubiquitination IDA
IDA: 通过直接分析推断
17314412 GOA
involved in suppression of viral release by host IDA
IDA: 通过直接分析推断
18248090 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
11331580 GOA
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
17314412 GOA
located in perinuclear endoplasmic reticulum IDA
IDA: 通过直接分析推断
17314412 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TRIM13 蛋白结构

zf-RING_2

zf-RING_2: Ring finger domain (9 - 58)

zf-B_box

zf-B_box: B-box zinc finger (90 - 131)

  • 0
  • 100
  • 200
  • 300
  • 407 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase TRIM13

B-cell chronic lymphocytic leukemia tumor suppressor Leu5

TRIM13 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TRIM13 O60858 FLJ13057 Homo sapiens Q53SE7
Y2H Array
25416956
种属内
TRIM13 O60858 FLJ13057 Homo sapiens Q53SE7
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Leukemia

Leukemias

Leukaemia, Unspecified, Without Mention Of Remission

Aleukemic Leukaemia

Chronic Leukaemia

Subacute Leukaemia

Leukaemia Disorder

Leukaemia Nos
Psoriasis 11

PSORS11

Psoriasis Susceptibility 11

Psoriasis

Psoriasis Vulgaris

Psoriasis 11, Susceptibility To

Pv
Adrenal Gland Pheochromocytoma

Pheochromocytoma
Pain Agnosia

Analgesia
Agnosia

Dyspraxia

Primary Visual Agnosia

Dyspraxia Syndrome

Monomodal Visual Amnesia

Visual Amnesia

Agnosia, Primary Visual

Apraxias

Alexia
Late-Onset Retinal Degeneration

LORD

Retinal Degeneration, Late-Onset, Autosomal Dominant

Autosomal Dominant Late-Onset Retinal Degeneration

Pigmentary Retinopathy

Retinal Degeneration, Late-Onset

Retinitis Pigmentosa
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15021 TRIM13 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris TRIM13 VGNC VGNC:47805
Rattus norvegicus TRIM13 RGD RGD:1307609
Felis catus TRIM13 VGNC VGNC:69301
Bos taurus TRIM13 VGNC VGNC:36314
Mus musculus TRIM13 MGD MGI:1913847
Macaca mulatta TRIM13 VGNC VGNC:79972
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