GDF11 - growth differentiation factor 11 Gene

中文名称：生长分化因子 11

种属: Homo sapiens

同用名: VHO; BMP11; BMP-11

基因 ID: 10220 | 基因类型: protein coding

关于 GDF11

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:55,743,122-55,757,264 (from NCBI)

This gene has 2 transcripts (splice variants), 120 orthologues, 31 paralogues and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 8.1), endometrium (RPKM 6.4) and 24 other tissues.

功能概要

该基因编码 TGF-β (转化生长因子-β) 蛋白质超家族的分泌配体。该家族的配体结合各种 TGF-β 受体，导致调节基因表达的 SMAD 家族转录因子的募集和激活。编码的前原蛋白经过蛋白水解处理，生成二硫键连接的同型二聚体的每个亚基。这种蛋白质在神经和其他器官系统的发育中发挥作用，并可能调节衰老。[RefSeq 提供，2016 年 8 月]

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role in the development of the nervous and Other organ systems, and may regulate aging. [provided by RefSeq, Aug 2016]

GDF11 基因产物(1)

mRNA	Protein	Name
NM_005811.5	NP_005802.1	growth/differentiation factor 11 preproprotein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	18596030	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in activin receptor signaling pathway	IMP IMP: 通过突变表型推断	28257634	GOA
involved in positive regulation of SMAD protein signal transduction	IMP IMP: 通过突变表型推断	28257634	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of protein-containing complex	IDA IDA: 通过直接分析推断	24019467	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GDF11 蛋白结构

TGFb_propeptide

TGF_beta

0
100
200
300
407 a.a.

蛋白主名

其他名称

growth/differentiation factor 11

GDF-11

GDF11 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	GDF11	O95390	ACVR2B	Homo sapiens	Q13705	SPR	21054789

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 GDF11 蛋白

目录号	产品名	蛋白编号	纯度
HY-P700020AF	Animal-Free GDF-11/BMP-11 Protein, Human (His)	O95390 (N299-S407)	≥95%
HY-P70222Y	GDF-11/BMP-11 Protein, Human (HEK293, solution)	O95390 (N299-S407)	≥95%

关联疾病

疾病名称

别名

Vertebral Hypersegmentation And Orofacial Anomalies

VHO

Orofacial Clefting Syndrome

Orofacial Clefting

Orofacial Cleft

Cleft, Orofacial

Aging

Cleft Lip With Or Without Cleft Palate

Tessier Cleft Number 1,2

Myostatin-Related Muscle Hypertrophy

Mslhp

Muscle Hypertrophy Syndrome

Sacral Defect With Anterior Meningocele

Caudal Regression Syndrome	Caudal Regression Sequence
Sacral Agenesis	Caudal Dysgenesis Syndrome
SDAM	Caudal Dysplasia Sequence
Caudal Dysplasia	Sacral Agenesis Syndrome
Sacral Regression Syndrome	Sacral Defect And Anterior Sacral Meningocele
Rudd Klimek Syndrome	Sirenomelia

Renal Hypodysplasia/Aplasia 1

Renal Agenesis	Renal Adysplasia
Renal Aplasia	RHDA1
Hereditary Renal Aplasia	Hra
Hereditary Urogenital Adysplasia	Hypodysplasia/Aplasia, Renal, Type 1
Congenital Absence Of Kidneys Syndrome	Congenital Absence Of Kidney
Aplastic Kidney

Osteoporosis

Postmenopausal Osteoporosis	Osteoporosis, Postmenopausal
Bone Mineral Density Quantitative Trait Locus	Bmnd
Osteoporosis, Involutional	Osteoporosis, Susceptibility To
Osteoporosis, Postmenopausal, Susceptibility	Bone Mineral Density Variation Qtl, Osteoporosis
OSTEOP	Involutional Osteoporosis
Senile Osteoporosis	Osteoporosis Postmenopausal
Bone Mineral Density, Quantitative Trait Locus	Osteoporosis, Senile
Idiopathic Osteoporosis	Bone Rarefaction Nos
Type 1 Osteoporosis

Cleft Palate, Isolated

Cleft Palate	Isolated Cleft Palate
CPI	Cp
Palatoschisis	Cleft Palate Isolated
Uranostaphyloschisis	Congenital Fissure Of Palate
Cleft Of Secondary Palate

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	是否罕见病
HY-P99720	Luspatercept	Inhibitor	98.92%	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05351	GDF11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P990733	Cibotercept	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	GDF11	VGNC	VGNC:62502
Bos taurus	GDF11	VGNC	VGNC:29300
Mus musculus	GDF11	MGD	MGI:1338027
Rattus norvegicus	GDF11	RGD	RGD:2673
Canis familiaris	GDF11	VGNC	VGNC:41159
Macaca mulatta	GDF11	VGNC	VGNC:82150

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

GDF11 - growth differentiation factor 11 Gene

关于 GDF11

功能概要

GDF11 基因产物(1)

GDF11 蛋白结构

GDF11 蛋白互作信息

重组 GDF11 蛋白

关联疾病

直系同源

热门区域

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GDF11 - growth differentiation factor 11 Gene

关于 GDF11

功能概要

GDF11 基因产物(1)

GDF11 蛋白结构

GDF11 蛋白互作信息

重组 GDF11 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z