IRX5 - iroquois homeobox 5 Gene

中文名称：易洛魁人同源盒 5

种属: Homo sapiens

同用名: HMMS; IRXB2; IRX-2a

基因 ID: 10265 | 基因类型: protein coding

关于 IRX5

Cytogenetic location: 16q12.2 Genomic coordinates (GRCh38): 16:54,930,865-54,934,485 (from NCBI)

This gene has 4 transcripts (splice variants), 260 orthologues, 6 paralogues and is associated with 3 phenotypes. Biased expression in lung (RPKM 4.8), skin (RPKM 3.3) and 10 other tissues.

功能概要

该基因编码易洛魁人同源盒基因家族的成员，该家族参与多个胚胎发育过程。敲除该基因的小鼠表明，它是视网膜锥体双极细胞分化所必需的，并且它负向调节心脏中的钾通道基因表达以确保协调的心脏复极化。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 11 月]

This gene encodes a member of the iroquois homeobox gene family, which are involved in several embryonic developmental processes. Knockout mice lacking this gene show that it is required for retinal cone bipolar cell differentiation, and that it negatively regulates Potassium Channel gene expression in the heart to ensure coordinated cardiac repolarization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

IRX5 基因产物(2)

mRNA	Protein	Name
NM_001252197.1	NP_001239126.1	iroquois-class homeodomain protein IRX-5 isoform 2
NM_005853.6	NP_005844.4	iroquois-class homeodomain protein IRX-5 isoform 1

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in embryonic cranial skeleton morphogenesis	IMP IMP: 通过突变表型推断	22581230	GOA
involved in gonad development	IMP IMP: 通过突变表型推断	22581230	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IRX5 蛋白结构

Homeobox_KN

0
100
200
300
400
483 a.a.

蛋白主名

其他名称

iroquois-class homeodomain protein IRX-5

homeodomain protein IRX-2A

关联疾病

疾病名称

别名

Hamamy Syndrome

HMMS	Hypertelorism, Severe, With Midface Prominence, Myopia, Mental Retardation, And Bone Fragility
Facial Dysmorphism-Ocular Anomalies-Osteopenia-Intellectual Disability-Dental Anomalies Syndrome

Cone Dystrophy

Retinal Cone Dystrophy	Dystrophy, Cone
Cone Dystrophy 3

Hypertelorism

Eyes Wide Apart	Eyes Widely Set
Hypertelorism Of Orbit	Ocular Hypertelorism
Orbital Separation Excessive

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Sensorineural Hearing Loss

Sensory Hearing Loss	Sensorineural Deafness
Sensorineural Hearing Loss Disorder	Hearing Loss, Sensorineural
Central Hearing Loss	High Frequency Deafness
High Frequency Hearing Loss	High-Frequency Hearing Loss
Perceptive Deafness	Perceptive Hearing Loss
Perceptive Hearing Loss Or Deafness	Hearing Loss Sensorineural
Deafness Sensorineural	Hearing Loss High-Frequency
Hearing Loss, Central	Hearing Loss, High-Frequency

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06924	IRX5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	IRX5	VGNC	VGNC:30289
Canis familiaris	IRX5	VGNC	VGNC:52139
Macaca mulatta	IRX5	VGNC	VGNC:73593
Rattus norvegicus	IRX5	RGD	RGD:1565518
Mus musculus	IRX5	MGD	MGI:1859086

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

IRX5 - iroquois homeobox 5 Gene

关于 IRX5

功能概要

IRX5 基因产物(2)

IRX5 蛋白结构

关联疾病

直系同源

热门区域

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IRX5 - iroquois homeobox 5 Gene

关于 IRX5

功能概要

IRX5 基因产物(2)

IRX5 蛋白结构

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z