2. Gene
  3. CCNO - cyclin O Gene

CCNO - cyclin O Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：细胞周期蛋白 O

种属: Homo sapiens

同用名: CCNU; UDG2; CILD29

基因 ID: 10309 | 基因类型: protein coding

关于 CCNO

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:55,231,152-55,233,608 (from NCBI)

This gene has 2 transcripts (splice variants), 231 orthologues, 18 paralogues and is associated with 3 phenotypes. Broad expression in testis (RPKM 3.3), stomach (RPKM 2.3) and 16 other tissues.

功能概要

该基因编码细胞周期蛋白家族的一个成员，所编码的蛋白质参与细胞周期的调节。该基因的破坏与原发性纤毛运动障碍 19 有关。可变剪接导致多个转录本变体。该基因之前的符号为 UNG2，在 PubMed ID：2001396 中被错误地鉴定为尿嘧啶 DNA 糖基化酶。后来的出版物 PubMed ID：8419333 将该基因的产物鉴定为细胞周期蛋白家族成员。 UNG2 符号也用作 UNG 基因 (GeneID 7374) 的特定蛋白质亚型名称，因此科学文献和一些数据库中对这两个基因存在混淆。[RefSeq 提供，2014 年 7 月]

This gene encodes a member of the cyclin protein family, and the encoded protein is involved in regulation of the cell cycle. Disruption of this gene is associated with primary ciliary dyskinesia-19. Alternative splicing results in multiple transcript variants. This gene, which has a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase in PubMed ID: 2001396. A later publication, PubMed ID: 8419333, identified this gene's product as a cyclin protein family member. The UNG2 symbol is also used as a specific protein isoform name for the UNG gene (GeneID 7374), so confusion exists in the scientific literature and in some databases for these two genes. [provided by RefSeq, Jul 2014]

CCNO 基因产物(1)

mRNA Protein Name
NM_021147.5 NP_066970.3 cyclin-O
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cilium assembly IMP
IMP: 通过突变表型推断
24747639 GOA
involved in mitotic cell cycle IDA
IDA: 通过直接分析推断
8419333 GOA
involved in multi-ciliated epithelial cell differentiation IMP
IMP: 通过突变表型推断
24747639 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
24747639 GOA
located in nucleolus IDA
IDA: 通过直接分析推断
28860486 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CCNO 蛋白结构

Cyclin_N

Cyclin_N: Cyclin, N-terminal domain (106 - 228)

Cyclin_C

Cyclin_C: Cyclin, C-terminal domain (231 - 325)

  • 0
  • 100
  • 200
  • 300
  • 350 a.a.
蛋白主名 其他名称

cyclin-O

cyclin U

CCNO 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CCNO P22674 TLE5 Homo sapiens Q08117-2
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Ciliary Dyskinesia, Primary, 29

Primary Ciliary Dyskinesia 29

CILD29

Ciliary Dyskinesia, Primary, 29, Without Situs Inversus

Primary Ciliary Dyskinesia 29 Without Situs Inversus

Primary Ciliary Dyskinesia Without Situs Inversus

Dyskinesia, Ciliary, Primary, Type 29
Primary Ciliary Dyskinesia

Immotile Cilia Syndrome

Kartagener Syndrome

Dextrocardia Bronchiectasis And Sinusitis

Pcd

Ciliary Motility Disorders

Ciliary Motility Disorder

Immotile Ciliary Syndrome

Ciliary Dyskinesia Primary

Ics

Polynesian Bronchiectasis

Dextrocardia-Bronchiectasis-Sinusitis Syndrome

Immotile Cilia Syndrome, Kartagener Type

Primary Ciliary Dyskinesia And Situs Inversus

Primary Ciliary Dyskinesia, Kartagener Type

Siewert Syndrome

Dyskinesia, Ciliary, Primary
Bronchiectasis

Polynesian Bronchiectasis

Kartagener Syndrome

Bronchiectasis Nos
Chromosome 17q12 Duplication Syndrome

17q12 Microduplication Syndrome

Trisomy 17q12

17q12 Duplication

17q12 Microduplication

Dup(17)(Q12)

Recurrent Duplication Of 17q12

17q12 Duplication Syndrome

17q12 Recurrent Duplication
Chronic Rhinitis

Rhinitis - Chronic

Chronic Rhinitis Nos

Rhinitis

Rhinitis Nos
Situs Inversus

Situs Inversus Viscerum

Laterality Sequence

Complete Transposition

Siv
Otorrhea

Discharging Ear
Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations

Star Syndrome

Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome

Syndactyly With Renal And Anogenital Malformations

STAR

Syndactyly, Telecanthus, Anogenital And Renal Malformations

Toe Syndactyly, Telecanthus, Anogenital And Renal Malformations
Kartagener Syndrome

Kartagener'S Syndrome
Visceral Heterotaxy

Situs Ambiguus

Heterotaxia

Heterotaxy Syndrome

Heterotaxy

Lateralization Defect

Situs Ambiguous

Left Isomerism

Htx

Ivemark Syndrome

Right Isomerism

Situs Ambiguus Viscerum

Incomplete Situs Inversus

Partial Situs Inversus

Heterotaxy, Visceral

Asplenia Syndrome

Bilateral Left-Sidedness

Polysplenia Syndrome

Moller Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02138 CCNO Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CCNO VGNC VGNC:52117
Bos taurus CCNO VGNC VGNC:26977
Rattus norvegicus CCNO RGD RGD:1565217
Macaca mulatta CCNO VGNC VGNC:70824
Mus musculus CCNO MGD MGI:2145534
Felis catus CCNO VGNC VGNC:60567
Others CCNO NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z