2. Gene
  3. B3GALT5 - beta-1,3-galactosyltransferase 5 Gene

B3GALT5 - beta-1,3-galactosyltransferase 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：β-1,3-半乳糖基转移酶 5

种属: Homo sapiens

同用名: B3T5; GLCT5; B3GalTx; B3GalT-V; beta3Gal-T5; beta-3-Gx-T5; beta-1,3-GalTase 5

基因 ID: 10317 | 基因类型: protein coding

关于 B3GALT5

Cytogenetic location: 21q22.2 Genomic coordinates (GRCh38): 21:39,612,940-39,673,137 (from NCBI)

This gene has 11 transcripts (splice variants), 313 orthologues and 15 paralogues. Biased expression in small intestine (RPKM 5.1), colon (RPKM 4.2) and 3 other tissues.

功能概要

该基因编码膜结合糖蛋白家族的一个成员。编码的蛋白质可以合成 1 型 Lewis 抗原，这种抗原在胃肠道和胰腺癌中升高。已经观察到该基因使用多个替代启动子的选择性剪接转录物变体。[RefSeq 提供，2017 年 9 月]

This gene encodes a member of a family of membrane-bound glycoproteins. The encoded protein may synthesize type 1 Lewis antigens, which are elevated in gastrointestinal and pancreatic cancers. Alternatively spliced transcript variants using multiple alternate promoters have been observed for this gene. [provided by RefSeq, Sep 2017]

B3GALT5 基因产物(8)

mRNA Protein Name
NM_001278650.2 NP_001265579.1 beta-1,3-galactosyltransferase 5 isoform a
NM_001356336.2 NP_001343265.1 beta-1,3-galactosyltransferase 5 isoform a
NM_001356338.2 NP_001343267.1 beta-1,3-galactosyltransferase 5 isoform a
NM_001356339.2 NP_001343268.1 beta-1,3-galactosyltransferase 5 isoform a
NM_006057.3 NP_006048.1 beta-1,3-galactosyltransferase 5 isoform a
NM_033170.3 NP_149360.1 beta-1,3-galactosyltransferase 5 isoform a
NM_033171.3 NP_149361.1 beta-1,3-galactosyltransferase 5 isoform a
NM_033172.3 NP_149362.2 beta-1,3-galactosyltransferase 5 isoform b
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

B3GALT5 蛋白结构

Galactosyl_T

Galactosyl_T: Galactosyltransferase (72 - 260)

  • 0
  • 100
  • 200
  • 310 a.a.
蛋白主名 其他名称

beta-1,3-galactosyltransferase 5

UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5

B3GALT5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
B3GALT5 Q9Y2C3 CLEC2D Homo sapiens Q9UHP7-3
Y2H Array
32296183
种属内
B3GALT5 Q9Y2C3 CLEC2D Homo sapiens Q9UHP7-3
Y2H Prey Pooling
32296183
种属内
B3GALT5 Q9Y2C3 DEFB103A Homo sapiens P81534
Y2H Array
32296183
种属内
B3GALT5 Q9Y2C3 DEFB103A Homo sapiens P81534
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 B3GALT5 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76738 B3GALT5 Protein, Human (HEK293, Fc) Q9Y2C3 (N29-V310) ≥95%
HY-P76739 B3GALT5 Protein, Human (sf9, His) Q9Y2C3 (N29-V310) ≥95%

关联疾病

疾病名称 别名
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01305 B3GALT5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus B3GALT5 VGNC VGNC:56202
Canis familiaris B3GALT5 VGNC VGNC:38336
Macaca mulatta B3GALT5 VGNC VGNC:70206
Felis catus B3GALT5 VGNC VGNC:68955
Rattus norvegicus B3GALT5 RGD RGD:1306727
Mus musculus B3GALT5 MGD MGI:2136878
Others B3GALT5 NCBI
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