IRF9 - interferon regulatory factor 9 Gene

中文名称：干扰素调节因子 9

种属: Homo sapiens

同用名: p48; IRF-9; ISGF3; ISGF3G

基因 ID: 10379 | 基因类型: protein coding

关于 IRF9

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:24,161,265-24,166,565 (from NCBI)

This gene has 70 transcripts (splice variants), 1 gene allele, 277 orthologues, 8 paralogues and is associated with 1 phenotype. Ubiquitous expression in spleen (RPKM 55.3), appendix (RPKM 34.4) and 25 other tissues.

功能概要

该基因编码干扰素调节因子 (IRF) 家族的一个成员，该家族是一组具有不同作用的转录因子，包括病毒介导的干扰素激活以及细胞生长、分化、凋亡和免疫系统活性的调节。 IRF 家族成员的特征是包含色氨酸 (W) 重复序列的保守 N 端 DNA 结合域。该基因的突变导致免疫缺陷 65。[RefSeq 提供，2020 年 7 月]

This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, Apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Mutations in this gene result in Immunodeficiency 65. [provided by RefSeq, Jul 2020]

IRF9 基因产物(4)

mRNA	Protein	Name
NM_001385400.1	NP_001372329.1	interferon regulatory factor 9 isoform 1
NM_001385401.1	NP_001372330.1	interferon regulatory factor 9 isoform 3
NM_001385402.1	NP_001372331.1	interferon regulatory factor 9 isoform 4
NM_006084.5	NP_006075.3	interferon regulatory factor 9 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP IMP: 通过突变表型推断	24882218	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17923090	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	24065129	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of ISGF3 complex	IPI IPI: 通过物理相互作用推断	24065129	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IRF9 蛋白结构

IRF

IRF-3

0
100
200
300
393 a.a.

蛋白主名

其他名称

interferon regulatory factor 9

IFN-alpha-responsive transcription factor subunit

IRF9 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	IRF9	Q00978	STAT2	Homo sapiens	P52630	Anti Tag CoIP	21903422
种属内	IRF9	Q00978	STAT2	Homo sapiens	P52630	Anti Bait CoIP	17923090
种属内	IRF9	Q00978	STAT2	Homo sapiens	P52630	Anti Tag CoIP	33961781
种属内	IRF9	Q00978	STAT2	Homo sapiens	P52630	Anti Tag CoIP	28514442
种属内	IRF9	Q00978	STAT2	Homo sapiens	P52630	Crosslink	24065129
种属内	IRF9	Q00978	IFNAR2	Homo sapiens	P48551	Anti Tag CoIP	17923090
种属内	IRF9	Q00978	IFNAR2	Homo sapiens	P48551	Anti Bait CoIP	17923090

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Immunodeficiency 65 Viral Infections

Immunodeficiency 65, Susceptibility To Viral Infections	IMD65
Immunodeficiency 65

Immunodeficiency 65

Imd65

Immunodeficiency 65, Susceptibility To Viral Infections

Lymphocytic Choriomeningitis

Lcm	Lymphocytic Meningitis
Lymphocytic Choriomeningitis Virus Encephalomyelitis	Lymphocytic Meningoencephalitis
Non-Arthropod Borne Lymphocytic Choriomeningitis	Lcm - [Lymphocytic Choriomeningitis]
Benign Lymphocytic Meningitis	Meningitis Due To Lymphocytic Choriomeningitis Virus

Measles

Rubeola	Morbilli
Measles Nos	Koplik Spots

Herpes Simplex

Herpes Simplex Infections	Herpesvirus Hominis Disease
Herpes Simplex Disease	Herpesviral Infection Due To Herpes Simplex
Infections Due To Simplex Virus	Herpes Nos

Immunodeficiency 44

IMD44

Mumps

Parotitis Due To Mumps Virus	Mumps Nos
Epidemic Parotitis	Infectious Parotitis

Immunodeficiency 39

IMD39

Immunodeficiency, Type 39

Microphthalmia With Limb Anomalies

Waardenburg Anophthalmia Syndrome	Ophthalmoacromelic Syndrome
OAS	MLA
Anophthalmia-Syndactyly	Anophthalmia-Syndactyly Syndrome
Anophthalmos With Limb Anomalies	Anophthalmia Waardenburg Syndrome
Anophthalmos-Syndactyly	Ophthalmo-Acromelic Syndrome
Anophthalmia-Waardenburg Syndrome	Anophthalmos-Limb Anomalies Syndrome
Syndactyly-Anophthalmos Syndrome	Microphthalmia, With Limb Anomalies

Lymphopenia

Lymphocytopenia

Viral Infectious Disease

Viral Disease	Arbovirus Infections
Virus Infection	Virus Diseases
Viral Infection	Viral Infections
Virus Infections

Phlebotomus Fever

Pappataci Fever	Sandfly Fever
Sandfly-Borne Phleboviral Disease	Sandfly-Borne Arboviral Fever
Sandfly-Borne Bunyavirus Fever	Three Day Fever
Chitral Fever	Italy Summer Grippe
Italy Summer Grippe Influenza

Torch Syndrome

Herpangina

Vesicular Pharyngitis

West Nile Encephalitis

West-Nile Encephalitis	West Nile Fever
West Nile Fever Encephalitis	West Nile Fever With Encephalitis
West-Nile Fever	Encephalitis, West Nile Fever

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Aicardi-Goutières Syndrome	Encephalopathy With Basal Ganglia Calcification
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-P99666	Interferon alfa	Agonist	≥95.0%	Phase 4

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06913	IRF9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	IRF9	MGD	MGI:107587
Rattus norvegicus	IRF9	RGD	RGD:1308766
Felis catus	IRF9	VGNC	VGNC:80948
Canis familiaris	IRF9	VGNC	VGNC:42097
Macaca mulatta	IRF9	VGNC	VGNC:84361
Bos taurus	IRF9	VGNC	VGNC:30280
Others	IRF9	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

IRF9 - interferon regulatory factor 9 Gene

关于 IRF9

功能概要

IRF9 基因产物(4)

IRF9 蛋白结构

IRF9 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

IRF9 - interferon regulatory factor 9 Gene

关于 IRF9

功能概要

IRF9 基因产物(4)

IRF9 蛋白结构

IRF9 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z