2. Gene
  3. WFDC2 - WAP four-disulfide core domain 2 Gene

WFDC2 - WAP four-disulfide core domain 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：WAP 四二硫核心结构域 2

种属: Homo sapiens

同用名: HE4; WAP5; EDDM4; dJ461P17.6

基因 ID: 10406 | 基因类型: protein coding

关于 WFDC2

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:45,469,753-45,481,532 (from NCBI)

This gene has 7 transcripts (splice variants) and 100 orthologues. Biased expression in salivary gland (RPKM 317.9), endometrium (RPKM 117.3) and 8 other tissues.

功能概要

该基因编码的蛋白质是 WFDC 结构域家族的成员。 WFDC 域或 WAP 签名基序包含八个半胱氨酸，在蛋白质的核心形成四个二硫键，并在许多家族成员中起蛋白酶抑制剂的作用。该基因在肺上皮细胞中表达，也被发现在一些卵巢癌中表达。编码的蛋白质是一种小的分泌蛋白，可能参与精子的成熟。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a Protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008]

WFDC2 基因产物(1)

mRNA Protein Name
NM_006103.4 NP_006094.3 WAP four-disulfide core domain protein 2 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25362534 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

WFDC2 蛋白结构

WAP

WAP: WAP-type (Whey Acidic Protein) 'four-disulfide core' (32 - 73)

WAP

WAP: WAP-type (Whey Acidic Protein) 'four-disulfide core' (76 - 122)

  • 0
  • 100
  • 124 a.a.
蛋白主名 其他名称

WAP four-disulfide core domain protein 2

WAP domain containing protein HE4-V4

重组 WFDC2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71432 HE4/WFDC2 Protein, Human (HEK293, His) Q14508 (E31-F124) ≥95%

关联疾病

疾病名称 别名
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Malignant Ovarian Cyst
Ovarian Cyst

Ovarian Cysts
Mucinous Ovarian Cystadenoma

Mucinous Cystadenoma Of Ovary

Ovarian Mucinous Cystadenoma
Ovarian Mucinous Cystadenocarcinoma

Mucinous Cystadenocarcinoma Of Ovary
Ovarian Cystadenoma

Cystoma Serosum Simplex

Simple Cystoma Of Ovary

Simple Cystoma Of The Ovary
Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15811 WFDC2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris WFDC2 VGNC VGNC:54267
Rattus norvegicus WFDC2 RGD RGD:628757
Macaca mulatta WFDC2 VGNC VGNC:78993
Mus musculus WFDC2 MGD MGI:1914951
Bos taurus WFDC2 VGNC VGNC:36933
Others WFDC2 NCBI
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