CDX1 - caudal type homeobox 1 Gene

中文名称：尾型同源框 1

种属: Homo sapiens

基因 ID: 1044 | 基因类型: protein coding

关于 CDX1

Cytogenetic location: 5q32 Genomic coordinates (GRCh38): 5:150,166,778-150,184,558 (from NCBI)

This gene has 1 transcript (splice variant), 94 orthologues and 2 paralogues. Biased expression in colon (RPKM 56.3), small intestine (RPKM 34.1) and 2 other tissues.

功能概要

该基因是尾部相关同源框转录因子基因家族的成员。编码的 DNA 结合蛋白调节肠特异性基因表达和肠细胞分化。它已被证明可诱导肠道碱性磷酸酶基因的表达，并抑制 β-连环蛋白/T 细胞因子转录活性。[RefSeq 提供，2008 年 7 月]

This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of the intestinal Alkaline Phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional activity. [provided by RefSeq, Jul 2008]

CDX1 基因产物(1)

mRNA	Protein	Name
NM_001804.3	NP_001795.2	homeobox protein CDX-1

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	15774940	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	15774940	GOA
enables methyl-CpG binding	IDA IDA: 通过直接分析推断	28473536	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	19059241	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA
enables transcription cis-regulatory region binding	IDA IDA: 通过直接分析推断	24623306	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	15774940	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	24623306	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CDX1 蛋白结构

Caudal_act

Homeobox

0
100
200
265 a.a.

蛋白主名

其他名称

homeobox protein CDX-1

caudal type homeo box transcription factor 1

CDX1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CDX1	P47902	CEBPA	Homo sapiens	P49715	Y2H	19059241

种属间: 跨种属相互作用 种属内: 同种属相互作用

CDX1 抗体

目录号	产品名	应用	反应物种
HY-P82217	CDX1 Antibody (YA1962)	WB, ICC/IF	Human

关联疾病

疾病名称

别名

Esophagus Melanoma

Melanoma Of Esophagus	Melanoma Of Oesophagus
Oesophagus Melanoma	Esophageal Melanoma

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Bile Reflux

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Mesenchymal Chondrosarcoma

Chondrosarcoma, Mesenchymal

Chondrosarcoma Mesenchymal

Klippel-Feil Syndrome

Cervical Vertebral Fusion	Congenital Dystrophia Brevicollis
Cervical Fusion Syndrome	Klippel-Feil Deformity
Autosomal Dominant Klippel-Feil Syndrome	Congenital Synostosis Of Cervical Vertebrae
Klippel-Feil And Turner Syndrome	Klippel-Feil Deformity, Deafness And Facial Asymmetry
Klippel Feil Syndrome	Cervical Vertebral Fusion Syndrome
Dystrophia Brevicollis Congenita	Fusion Of Cervical Vertebrae
Kfs	Klippel-Feil Sequence
Vertebral Cervical Fusion Syndrome	Klippel-Feil Syndrome, Autosomal Dominant
Klippel-Feil Malformation	Isolated Klippel-Feil Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02429	CDX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	CDX1	VGNC	VGNC:110474
Bos taurus	CDX1	VGNC	VGNC:106683
Canis familiaris	CDX1	VGNC	VGNC:39084
Felis catus	CDX1	VGNC	VGNC:60722
Mus musculus	CDX1	MGD	MGI:88360
Rattus norvegicus	CDX1	RGD	RGD:621233

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CDX1 - caudal type homeobox 1 Gene

关于 CDX1

功能概要

CDX1 基因产物(1)

CDX1 蛋白结构

CDX1 蛋白互作信息

CDX1 抗体

关联疾病

直系同源

热门区域

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CDX1 - caudal type homeobox 1 Gene

关于 CDX1

功能概要

CDX1 基因产物(1)

CDX1 蛋白结构

CDX1 蛋白互作信息

CDX1 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z