UBD - ubiquitin D Gene

中文名称：泛素 D

种属: Homo sapiens

同用名: FAT10; UBD-3; GABBR1

基因 ID: 10537 | 基因类型: protein coding

关于 UBD

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:29,555,515-29,559,732 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 104 orthologues and 10 paralogues. Biased expression in lymph node (RPKM 113.8), appendix (RPKM 64.9) and 10 other tissues.

功能概要

该基因编码的蛋白质包含两个泛素样结构域，似乎具有与泛素相似的功能。通过共价连接，编码的蛋白质靶向其他蛋白质进行 26S 蛋白酶体降解。这种蛋白质与许多细胞过程有关，包括半胱天冬酶依赖性细胞凋亡、聚集体形成、有丝分裂调节和树突细胞成熟。该基因的上调可能会促进慢性肾脏疾病的炎症，并且已在许多癌症类型中观察到。[RefSeq 提供，2017 年 8 月]

This gene encodes a protein which contains two ubiquitin-like domains and appears to have similar function to ubiquitin. Through covalent attachment, the encoded protein targets Other proteins for 26S Proteasome degradation. This protein has been implicated to function in many cellular processes, including caspase-dependent Apoptosis, formation of aggresomes, mitotic regulation, and dendritic cell maturation. Upregulation of this gene may promote inflammation in chronic kidney disease and has been observed in many Cancer types. [provided by RefSeq, Aug 2017]

UBD 基因产物(1)

mRNA	Protein	Name
NM_006398.4	NP_006389.2	ubiquitin D

UBD 蛋白结构

ubiquitin

0
100
165 a.a.

蛋白主名

其他名称

ubiquitin D

diubiquitin

UBD 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	UBD	O15205	PDE9A	Homo sapiens	O76083-2	Y2H Prey Pooling	32296183
种属内	UBD	O15205	PDE9A	Homo sapiens	O76083-2	Validated Y2H	32296183
种属内	UBD	O15205	PDE9A	Homo sapiens	O76083-2	Y2H Array	32296183
种属内	UBD	O15205	NUB1	Homo sapiens	Q9Y5A7	Anti Tag CoIP	33961781
种属内	UBD	O15205	UBE2Z	Homo sapiens	Q9H832	Anti Tag CoIP	24528925
种属内	UBD	O15205	UBE2Z	Homo sapiens	Q9H832	Anti Bait CoIP	24528925
种属内	UBD	O15205	MAPK8IP2	Homo sapiens	Q13387	Validated Y2H	25814554
种属内	UBD	O15205	SNCA	Homo sapiens	P37840	Validated Y2H	32814053
种属内	UBD	O15205	SNCA	Homo sapiens	P37840	Y2H Array	32814053
种属内	UBD	O15205	SNCA	Homo sapiens	P37840	Y2H Pooling	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Kidney Disease

Renal Failure	Kidney Failure
Kidney Diseases	Nephropathy
Abnormality Of The Kidney	Impaired Renal Function Disease
Renal Anomaly	Kidney Dysfunction
Renal Disease	Nephropathies
Renal Failure Adverse Event	Abnormal Renal Function

Chronic Kidney Disease

Chronic Renal Disease	Chronic Kidney Failure
Ckd	Chronic Renal Failure
Kidney Failure, Chronic	Chronic Renal Failure Syndrome
Crf	Renal Failure - Chronic
Renal Failure Chronic	Chronic Kidney Diseases
Chronic Kidney Disease Stage 5	Ckd - [Chronic Kidney Disease]
Crf - [Chronic Renal Failure]	Chronic Kidney Impairment
Chronic Renal Impairment	Chronic Kidney Shutdown
Chronic Hypoxic Kidney Failure	Chronic Kidney Collapse
Chronic Renal Insufficiency	Chronic Kidney Toxaemia
Chronic Kidney Hypofunction	Chronic Renal Suppression
Chronic Renal Failure, Stage 5	Ckd - [Chronic Kidney Disease] Stage 5
End Stage Kidney Failure	End Stage Renal Failure
End Stage Kidney Disease	End Stage Renal Disease
End Stage Chronic Renal Failure	Esrf - [End Stage Renal Failure]
Esrd - [End Stage Renal Diseases]	Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Polycystic Kidney Disease

Polycystic Kidney Diseases	Pkd
Polycystic Renal Disease	Kidney Disease, Polycystic
Polycystic Kidney, Autosomal Dominant

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-139979	USP5-IN-1	Inhibitor	99.73%	否
HY-155697	SGC-UBD253	Antagonist	99.3%	否
HY-RS15335	UBD Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-157428	USP3 ZnF-UBD ligand-1		/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	UBD	VGNC	VGNC:104439
Rattus norvegicus	UBD	RGD	RGD:69418
Mus musculus	UBD	MGD	MGI:1344410
Others	UBD	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

UBD - ubiquitin D Gene

关于 UBD

功能概要

UBD 基因产物(1)

UBD 蛋白结构

UBD 蛋白互作信息

关联疾病

直系同源

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UBD - ubiquitin D Gene

关于 UBD

功能概要

UBD 基因产物(1)

UBD 蛋白结构

UBD 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z